Expression of miR-195-5p and wnt3a in the CORM-3-induced osteogenic differentiation of rat BMSCs
As indicated in Fig. 2A, miR-195-5p level in cells cultured in COMR-3 group was obviously decreased compared with osteogenic group and control group on 24 hours (P < 0.05). The protein expression of wnt3a was enhanced during the CORM-3-induced osteogenic differentiation of rat BMSCs (Fig. 2B). At 24, 48 and 72 hours, the protein expressions of wnt3a in COMR-3 group were increased by 3.3, 1.5 and 1.3-fold compared with osteogenic group, respectively (P < 0.05).