Concluision
In summary, this study intervened the growth of CRSwNP tissues by
glucocorticoids, analyzed the differential gene expression of
transcriptomes from normal CRSwNP tissues, and initially predicted that
the RPL26 gene played an important role in the process of edema of
CRSwNP tissues. Then we established the RPL26 silencing and
overexpressing CRSwNP cell system through CRISPR-Case9 gene editing
technology, and studied the effect of RPL26 silencing and overexpression
on CRSwNP tissue edema. It was initially verified that the high
expression of RPL26 gene can reduce the degree of CRSwNP tissue edema,
proving that RPL26 gene plays an important role in the regulation of
CRSwNP tissue edema. However, the mechanism by which the rpl26 gene
functions still needs further research and confirmation.