FIGURE LEGENDS
FIGURE 1. Kaplan-Meier analysis of progression-free survival in relation to interim PET/CT results using the DC-3(A), post-treatment PET/CT results using the IHPC(B), DC-3(C) and DC-4(D) criteria respectively.
Figure 2 and figure 3 are typical examples of baseline, interim and post-treatment PET/CT scans of pediatric and adolescent patients with HL, which have not been cited in the text.
FIGURE 2 A 13-year-old boy with stage Ⅱ Hodgkin lymphoma. (A) Coronal PET/CT images before treatment show disseminated metabolically active lesions in the cervical and mediastinal areas. (B) Interim coronal PET/CT images after 2 cycles of chemotherapy show that the residual uptake is markedly higher than the liver. This result corresponded to a Deauville Criteria (DC) score of 5 and a positive International Harmonization Project Criteria (IHPC) score. (C) Post-treatment coronal PET/CT images show that at the end of therapy, a few cervical lymph nodes have a slightly high FDG uptake (yellow arrow). (D) Post-treatment merged axial PET/CT images show a residual cervical lymph node (10 mm) with an activity above that of the surrounding background. This result corresponded to a DC score of 3 and a positive IHPC score. This patient showed continuous complete remission after a follow-up of 17 months.
FIGURE 3 A 19-year-old girl with stage Ⅳ Hodgkin lymphoma. (A) Coronal PET/CT images before treatment show intense tracer uptake in the bilateral cervical lymph nodes, mediastinum, left armpit, left pulmonary hilum, and bone marrow. (B) Interim coronal PET/CT images show that after 2 cycles of chemotherapy, the residual uptake in the bilateral cervical lymph nodes, mediastinum, and left armpit is markedly higher than the uptake in the liver. This result corresponds to a Deauville Criteria (DC) score of 5 and a positive International Harmonization Project Criteria (IHPC) score. (C) Post-treatment coronal PET/CT images show that at the end of therapy, the uptake of a residual left supraclavicular lymph node and a residual left axillary lymph node is moderately higher than that of the liver (yellow arrow). (D) Post-treatment axial fused PET/CT images show a residual left supraclavicular lymph node smaller than 2 cm. (E) A residual left axillary lymph node greater than 2 cm on CT images. This result corresponds to a DC score of 4 and a positive IHPC score, and may be a false positive caused by inflammation. This patient showed continuous complete remission after a follow-up of 22 months.