Correlation of strain parameters with myocardial function
We observed that LV-GS had a significant correlation with LVEF (r=-0.726; 95% CI: -0.801 to -0.629) and LVMI (r=0.451; 95% CI: 0.296-0.582). Additionally, we found that LA-GS had its strongest correlation with LA-Volume (r=-0.453, 95%CI: -0.584 to -0.298) and with LVMI (r= -0.398, 95% CI: -0.538 to -0.236). In the prediction of myocardial function, we found that LV-GS predicted 64.6% and LA-GS 14.1% of LVEF variability. Also, both LV-GS and LA-GS predicted LVMI and RWT parameters (Figure 3 ). Exploring the subgroups of subjects with previous myocardial infarction, we found that these patients had lower LV-GS (p<0.001) and lower LA-GS (p<0.032) compared to subjects without myocardial infarction. As expected, these subjects also had decreased LVEF (p<0.001) and eccentric hypertrophy with RWT (p<0.021) and LVMI (p<0.113) (Supplementary Figure 2) .