EXPERIMENTAL APPROACH
In this study, two mouse models of DSS
(the
concentration of 3% and 5%)-induced colitis and Caco2 and IEC-6 cells
were employed. The 16S amplicon
sequencing was used to assess Gut microbiota changes by diosmetin.
Various physical signs of mice (body weight, colon length and DAI
score), proinflammatory cytokines and antioxidant enzymes were tested.