CONCLUSIONS AND IMPLICATIONS
Our
results have linked colitis to the circ-Sirt1/Sirt1 signaling pathway,
which is regulated by diosmetin. It implies that diosmetin may be a
novel candidate to alleviate DSS-induced colitis or a lead compound for
future optimization and modification.
Keywords: diosmetin,
proinflammatory cytokines,
oxidative
stress, gut microbiota