Author contributions
H.L.L., Y.Y.W., X.H.L., H.G.Z. and
C.Y designed the experiments and wrote the manuscript.
H.L.L., Y.Y.W., H.R., J.H.L., and
S.S.Z. performed the animal and cell experiments. H.L.L., Y.Y.W. and
X.H.L. performed the quantitative real-time PCR and Western blotting
assays. Z.W.L and S.S.S. performed the immunofluorescence experiments.
R.T.Z. and B.W.M performed the Histopathological section. K.X.L. and
J.Y.P. edited the manuscript.