Relationship between the Microbiome, Metabolic Syndrome, and
Chronic Inflammation
Next we compared features of the microbiome and subject clinical
characteristics, including components of metabolic syndrome as well as
several markers of inflammation, amongst survivors. We did not observe a
statistically significant correlation with either Shannon or Simpson
Index and Hemoglobin A1c, High Density Lipoprotein, Low Density
Lipoprotein, Adiponectin- Leptin ratio, systolic blood pressure,
diastolic blood pressure, or body mass index (Supplementary
Table 1). We also did not observe a significant correlation between
Shannon or Simpson index and levels of C-Reactive protein, Tumor
Necrosis Factor alpha, or Interleukin-10 (Supplementary Table
2). A modest correlation was seen between Simpson index and levels of
Interleukin-6 amongst survivors (R=-0.41, P=0.02), but no correlation
was seen between Shannon index and Interleukin-6 levels (R=-0.04,
P=0.81).
We also examined differently abundant taxa in subjects based on
adiposity, body mass index and inflammation. Subjects with less
favorable Adiponectin-Leptin ratio (<1.0) had increased
abundance of multiple Bacteroides ASVs (Supplemental
Figure 3) . Survivors with differing body mass index and C-Reactive
protein levels also demonstrated differently abundant taxa after
adjusting for a FDR of 0.05 (Supplemental Figure 4, Supplemental
Figure 5) .