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Changed epidemiology of anthrax and molecular characteristics of B. anthracis in Inner Mongolia Autonomous Region, China
  • +12
  • yan hai,
  • wenrui wang,
  • hua yue,
  • weidong guo,
  • jian song,
  • han song,
  • yugeng zhang,
  • xiaofeng jiang,
  • xiuhong zhang,
  • zhenjun li,
  • wei li,
  • xudong liang,
  • runlin han,
  • jianchun wei,
  • Zhiguo Liu
yan hai
College of Veterinary Medicine, Inner Mongolia Agriculture University
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wenrui wang
Inner Mongolia Autonomous Region Center for Comprehensive Disease Control and Prevention
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hua yue
Inner Mongolia Autonomous Region Center for Comprehensive Disease Control and Prevention
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weidong guo
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yugeng zhang
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xiaofeng jiang
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xiuhong zhang
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zhenjun li
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xudong liang
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runlin han
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jianchun wei
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Zhiguo Liu
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
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Peer review status:UNDER REVIEW

03 Jul 2020Submitted to Transboundary and Emerging Diseases
03 Jul 2020Assigned to Editor
03 Jul 2020Submission Checks Completed
13 Jul 2020Reviewer(s) Assigned

Abstract

Anthrax is a natural foci disease in Inner Mongolia, which poses a severe threat to public health. In this study, the incidence number, rate, and constituent ratio were used to describe the epidemiological characteristics of anthrax in the region from 1956–2018. The molecular correlation and genetic characteristics of the strains were investigated using canonical single-nucleotide polymorphisms (CanSNP), multiple-locus variable-number tandem repeat analysis (MLVA-15), and whole genome sequencing (WGS). The epidemiological characteristics of anthrax in Inner Mongolia have altered significantly. The incidence was decreased annually, the regional distribution of anthrax gradually transferred from central and western regions to the eastern. Moreover, the occupation distribution was evolved from multiple early occupations to predominated by farmers and herdsmen. This indicates that reformulate the control and prevention strategies is essential. Both A. Br. Ames and A. Br. 001/002 subgroups were the predominant CanSNP genotypes of Bacillus anthracis in Inner Mongolia. A total of 36 strains constituted six shared MLVA-15 genotypes, suggesting an epidemiological link between the strains of each shared genotype. The six shared genotypes ((GT1, 9, 11, and 15) and (GT8 and 12)) consisting of 2–7 strains confirmed the occurrence of multiple point outbreaks and cross-regional transmission caused by multiple common sources of infection. Phylogenetic analysis based on the core genome showed that strains from this study formed an independent clade (CⅢ), suggesting a common origin. Moreover, B. anthracis showed a high genetic similarity with strain from Japan and South Korea, the strains from this study may be originated from Japan.