Material and Method
In our study between 2011-2019, among the 1393 kidney biopsy samples of
80 samples belong to diabetic patients. These 70 diabetic patients older
than 18 years were evaluated retrospectively. There were 38 DN, 32 PGN,
and 10 DN with superimposed diseases (such as DN + hypertensive
nephropathy, DN + crescentic GN) according to kidney biopsy. Ten
patients with superimposing conditions with DN were excluded from the
study.
Clinical-demographic characteristics, treatment, and laboratory results
of the patients were obtained from the medical records of our hospital.
Clinical-demographic characteristics; age, gender, body mass index,
smoking, blood pressure, DM duration, accompanying diseases
(Hypertension (HT), coronary artery disease (CAD), heart failure),
diabetic microvascular complications (diabetic retinopathy (DR),
diabetic neuropathy ( DNP)) and drugs used (ACEI (angiotensin-converting
enzyme inhibitor), ARB (Angiotensin receptor blocker), oral
antidiabetic, Insulin) were evaluated.
At the time of kidney biopsy and follow up period at 6. and 12 months;
biochemical parameters including fasting blood sugar, blood urea
nitrogen, creatinine, total protein, albumin, AST, ALT, sodium,
potassium, calcium, phosphorus, total cholesterol, HDL cholesterol, LDL
cholesterol, triglyceride, complete blood count, HbA1C, proteinuria in
24-hour urine and glomerular filtration rate (eGFR) were recorded. eGFR
was calculated according to CKD-EPI8. ADA (American
Diabetes Association) criteria were used in the diagnosis of type 2
DM9. AHA criteria were used for heart
failure10.
The diagnosis of DR was made by fundoscopy and/or fluorescein
angiography, and DNP was made by electromyogram (EMG). Patients using
antihypertensive drugs or blood pressure ≥ 140/90 were considered
hypertensive.