Introduction
Diabetic Nephropathy (DN) is the most common cause of renal involvement
in diabetic patients. It causes renal histopathological changes such as
glomerular basement membrane thickening, mesangial matrix increase,
diffuse or nodular glomerulosclerosis1. Typically,
early-stage hyperfiltration develops, followed by microalbuminuria and
macroalbuminuria, with slow progressive renal dysfunction. Ultimately,
it causes end-stage kidney disease (ESRD)2.
Non-diabetic kidney disease (NDKD) prevalence may vary depending on
renal biopsy selection criteria, and its frequency shows significant
variations3. In renal biopsy samples of diabetic
patients, 1/3 DN only, 1/3 NDKD, and 1/3 DN and disease have been
reported4,5. Renal biopsy in diabetic patients is
performed in suspicious cases, not routinely6. The
diagnosis of NDKD is closely related to clinical findings, clinician
opinion, and center experience. Besides, its treatment and prognosis are
quite different from DN. In a diabetic patient, sudden onset
proteinuria, the rapid loss of kidney function, active urinary sediment,
and the short-term history of DM may be clues for additional
pathologies3,7.
Retrospective single-center study, we investigated the clinical,
laboratory, and pathological differences of patients with biopsy-proven
DN and PGN patients with type 2 DM.