FUNDING
This work was supported by the National Natural Science Foundation of China for Young Scholar (Grant No.81600556,81700653,81700597,81800608); Major Research plan of the National Natural Science Foundation of China (Grant No. 91742204); International (regional) cooperation and exchange projects, (NSFC-DFG, Grant No. 81761138041); National Natural Sciences Foundation of China (Grants 81470948, 81670633,81570669, 81570615); the National key research and development program (Grants 2016YFC0906103); the National Key Technology R&D Program (Grant 2013BAI09B06,2015BAI12B07); The third project for the young and middle-aged excellent medical talents of Wuhan.
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