Introduction
Hypersensitivity reaction to mediations is not an uncommon phenomenon in cancer patients, but anaphylaxis to commonly used infusion lines, particularly low sorb tubing has not been previously reported in the literature. The possibility of adverse effects from interaction between blood and plastic tubing created some concern in the early days of medical care. The mechanisms responsible for most of these reactions are unknown, and these reactions may be immunologic or non-immunologic. The clinical presentation of these reactions can vary from mild cutaneous reactions to severe life-threatening reactions. These life-threatening anaphylactic reactions can limit the use of front-line chemotherapeutic agents making it imperative to accurately find the inciting factor so that appropriate chemotherapy can continue. Here we present a unique case of a child with brain cancer and Hashimoto thyroiditis, who developed an allergic reaction to the IV tubing system.