Introduction
Hypersensitivity reaction to mediations is not an uncommon phenomenon in
cancer patients, but anaphylaxis to commonly used infusion lines,
particularly low sorb tubing has not been previously reported in the
literature. The possibility of adverse effects from interaction between
blood and plastic tubing created some concern in the early days of
medical care. The mechanisms responsible for most of these reactions are
unknown, and these reactions may be immunologic or non-immunologic. The
clinical presentation of these reactions can vary from mild cutaneous
reactions to severe life-threatening reactions. These life-threatening
anaphylactic reactions can limit the use of front-line chemotherapeutic
agents making it imperative to accurately find the inciting factor so
that appropriate chemotherapy can continue. Here we present a unique
case of a child with brain cancer and Hashimoto thyroiditis, who
developed an allergic reaction to the IV tubing system.