Conclusion
In summary, highly number of organ dysfunction (≥3), and highly
increased IL-6 (≥13.2pg/mL) at CRRT initiation are independent
prognostic factors for predicting early death in children with SHLH and
MODS. These findings may help guide the treatment decision making for
this disease to avoid insufficient therapy. In addition, IL-6 can be
designated as a particular cytokine biomarker for SHLH- associated MODS
patients. Inhibiting IL-6 may be a potential therapeutic strategy for
reversing these cases.