Conclusion
In summary, highly number of organ dysfunction (≥3), and highly increased IL-6 (≥13.2pg/mL) at CRRT initiation are independent prognostic factors for predicting early death in children with SHLH and MODS. These findings may help guide the treatment decision making for this disease to avoid insufficient therapy. In addition, IL-6 can be designated as a particular cytokine biomarker for SHLH- associated MODS patients. Inhibiting IL-6 may be a potential therapeutic strategy for reversing these cases.