Design and setting
We performed a
prospective
multicentre observational cohort study between August 2013 and July 2018
from 4 tertiary care PICUs in Shanghai. Fifty-two critically ill
children were enrolled in this study. The protocol was approved by each
institution’s ethics/investigation review board (2016R011-F01).Informed
to participation in the study consent was obtained from the guardians of
the patients.
Eligibility criteria for this study were as follows: 1) aged between 1
month and 18 years, 2) meet HLH-2004 and MODS diagnostic criteria, 3)
treated with HLH-2004 protocol, 4) receiving CRRT during the PICU
stay[9]. MODS was defined as the underlying primary disease process
leading to at least two organ system dysfuction at any time during PICU
stay[10]. Patients with familial history or known genetic
predisposition(primary HLH)were excluded from analysis. Data from
enrolled patients were entered into standardized electronic
case report forms (CRF).