Baseline Characteristics of Pediatric Patients With SHLH
Over the 5-year study period, a total of 114 patients were screened and 52 cases were enrolled. (Supplemental Digital Content 1). Among these patients, the mean age was 24.5 months (12–89 mo) and 28 patients (53.8%) were male. Of 52 patients with SHLH required CRRT, 24 patients died and overall hospital mortality was 46.15%. The characteristics of the patients included are shown in Supplemental Digital Content 2 The etiology of the SHLH disease was most frequently infection-related (n=46, 88.5%), among which 87.0% was EBV-SHLH (n=40). The common indications for PICU admission was hypoxemia (34.6%, n=18), cardiovascular dysfunction (28.9%, n=15), recurrent seizures (18.9%, n=10) or AKI (17.3%, n=9) .The main reasons for CRRT were fluid overload (FO) (42.3%, n=22), hepatic dysfunction (30.8%, n =16), acute kidney injury (AKI) (17.3%, n =9), and severe electrolyte imbalance (7.5%, n=4). The femoral vein was catheterized in 69.2% of patients (36/52), and the jugular vein in 30.8%(16/52). At the time of starting CRRT, mechanical ventilation required in 44.1% (33/52) patients, vasoactive drugs continuously infused in 28.8% (14/52) patients, and 23.1% (12/52) of them received diuretics. Anticoagulation was achieved using heparin in 69% of patients (36/52) and citrate in 31% of patients (16/52). The mean length of CRRT was 43 (24, 86.5) hours.