FIGURE 6 Genes involved in pathways that are associated with hepatic involvement (The X axis represents hepatic involvement severity the Y axis represents the normalized values of the genes. (A) AGE-RAGE signaling pathway in diabetic complications. (B) Cytokine-cytokine receptor interaction (C) Insulin resistance. (D) TNF signaling pathway. (E) Aldosterone regulated sodium reabsorption. (F) Type II diabetes mellitus. Bivariate correlation and spearman coefficient method analyses were performed using the SPSS program (IBM Statistics, Version 22) to establish a correlation between the clinical parameters determining the disease severity. (No hepatic involvement: Family 3, mild hepatic involvement: F1-P1, F2-P1, severe hepatic involvement; F1-P2, F2-P2).