FIGURE 4 Differentially expressed genes in CF patients (Family 1, 2 and 3). Significance was analyzed with unpaired student t-test. **: p≤0.01; *: p≤0.05. Up regulated gene (ICAM1; 4,29 FC). Down regulated genes (HSPA1A; -2,39 FC, TNFRSF1A; -2,43 FC and EZR; -7,27 FC).
Among the KEGG pathways that were enriched in WebGestalt analysis pathways involved in inflammation and immune response such as TNF signaling (p=8.38E-13), NF-kappa B signaling (p=6.69E-09), insulin resistance (7.08E-06) and cytokine-cytokine receptor interaction (p=4.19E-06) were detected as the most significant ones (Table 4).
TABLE 4 The list of pathways and differentially expressed genes in CF patients (Significantly expressed genes are shown in bold).