Differentially Expressed Genes Between Mild and Severe
Patients with Class IV Mutation
A total of 24 genes were demonstrated to be differentially expressed
(Table 3). Three of them were up regulated while 21 genes were down
regulated in severe sibling (F3-P3) compared to mild siblings (F3-P1 and
F3-P2). Although the statistical significance of differentially
expressed genes could not be evaluated, pathways were interpreted in
terms of biological significance. Among the KEGG pathways that were
enriched in WebGestalt analysis, the IL-17 signaling pathway
(p=4.48E-09), NOD-like receptor signaling pathway (p=2.75E-07), AGE-RAGE
signaling pathway in diabetic complications (p=7.24E-06),
cytokine-cytokine receptor interaction (p=1.17E-05), NF-kappa B
signaling pathway (p=5.91E-06), TNF signaling pathway (p=1.21E-05), and
TLR signaling pathway (p=0.0001) were found to be associated with
severity in Class IV.
TABLE 3 The differentially expressed genes in severe patient
with Class IV mutation.