Correlation Between Clinical Severity and Differentially
Expressed Genes
In order to investigate whether there is a correlation between clinical
parameters determining the disease severity such as recurrent lung
infection, FEV1% values, hepatic involvement, diabetes and
differentially expressed genes, bivariate correlation and spearman
coefficient method analyses were performed. 29 genes were found to have
a significant positive correlation with hepatic involvement. These genes
were involved in AGE-RAGE signaling pathway in diabetic complications;
p=1.62-06, cytokine-cytokine receptor interaction; p= 0.0047, insulin
resistance; p=0.0077, TNF signaling pathway; p=0.0083, aldosterone
regulated sodium reabsorpsion; p=0.0087, type II diabetes mellitus;
p=0.0133 pathways (Figure 6).