Reference values of impulse oscillometry (IOS) for healthy
Chinese children aged 4-18 years
Jinhong Wu, Hao Zhang
Department of Pulmonology, Shanghai Children’s Medical Center Affiliated
to Shanghai Jiao Tong University School of Medicine, Shanghai 200127,
China;
Abstract :
Objective : To establish the predicted value of lung function
determined by impulse oscillometry (IOS) in
children (4~17 years old) in China.
Methods : A total of 6270 healthy children aged 4 to 17 in
Shanghai were included. The Master Screen IOS pulmonary function device
(Jaeger Co, Germany) was used to detect the respiratory total impedance
(Zrs), response frequency (Fres), viscosity resistance (Rrs) and elastic
resistance (Xrs) at various oscillation frequencies, and the indexes
above were analyzed. The stepwise multivariate regression was used to
establish the regression equation of related parameters of IOS in
different genders. Results The median age of 6270 children (3345 boys
and 2925 girls) was 10 years, ranging from 4 to 17 years. The
differences in the main IOS parameters between different age and height
groups are statistically significant regardless of sex
(P<0.05). The values of Z5,
R5, R20, and Fres decreased with the
increase of age and height, while X5 increased with the
increase of age and height. The stepwise multivariate regression
analysis showed that IOS parameters were related to height, age, and
weight, and most IOS parameters were most closely related to height (the
absolute value of regression coefficient was the largest).
Conclusions: The study revealed the normal predicted value of pulmonary
function by IOS in healthy children in China. In the evaluation of the
results of the lung function measurements, the use of this predicted
value equation is more in line with the characteristics of Chinese
children than that of foreign countries.
Key words: impulse oscillometry; respiratory function test; normal
predicted value; child