Study population
This was a multicenter study covering 44156 patients in 52 cities (from
26 provinces, 7 geographical regions) of mainland China from July 2015
to June 2018. The patients suffered from clinical symptoms of suspected
allergic diseases, and serum allergen sIgE levels were detected. The
suspected allergic diseases included allergic rhinitis (such as runny
nose, sneezing, itching or nasal obstruction), skin allergy (such as
rashes, wheal, eczema, or urticaria), and allergic asthma (such as
wheezing, dyspnea, and/or cough not due to common cold). Patients with
parasitic infections, immunodeficiency or under specific immunotherapy
were excluded. The analyzed data covered the information on the medical
diagnosis, demographic data, and sIgE levels for nine allergens. This
study was approved by the ethics committee of the First Affiliated
Hospital of Guangzhou Medical University (Approval number:
GYFYY-2017-18).