Characteristics of study cohort
1235 cases were analyzed according to the inclusion criteria, including 181 cases of grade 3 (14.7%), 1054 cases of grade 1&2 (85.3%). For survival analysis, 53 grade 3 patients (13.9%) and 328 grade 1&2 patients (86.1%) were included respectively (Figure1).
The LNM rate (16.6%) in overall grade 3 population is around twice higher than that of grade 1&2 (9.4%). patients over 70 years old in grade 1&2 group presented with highest LNM rate. There is no obvious difference among these age subgroups of grade 3. EEC G3 patients with any of the following risk factors including LVSI, CSI, AI, or MI, the risk of LNM would increase by 3 to 5 folds (Table 1).
After adjusted for age, parametrium involvement and tumor size in multivariate analysis, we found LVSI, AI and CSI were independent risk factors for LNM (Adjusted OR=3.45, 5.83, 8.93; 95% CI 1.12-10.64, 1.52-22.35, 2.85-28.00 respectively) in EEC G3 cohort. LVSI, AI, MELF, MI (Adjusted OR=8.82, 3.40, 2.24, 5.02; 95% CI 4.88-15.96, 1.29-8.95, 1.28-3.93, 2.93-8.61, respectively) were independent risk factors among grade 1&2 cohort (Table 3). The overall population presented with similar trends with grade 1&2 subgroup (Adjusted OR=6.95, 3.21, 2.67, 4.30;95% CI 4.12-11.72, 1.51-6.81, 1.56-4.54, 2.66-6.94, respectively) (Table 2). For our data, we observed tumor size increased the risk of LNM for grade 1&2 other than grade 3.