Characteristics of study cohort
1235 cases were analyzed according to the inclusion criteria, including
181 cases of grade 3 (14.7%), 1054 cases of grade 1&2 (85.3%). For
survival analysis, 53 grade 3 patients (13.9%) and 328 grade 1&2
patients (86.1%) were included respectively (Figure1).
The LNM rate (16.6%) in overall grade 3 population is around twice
higher than that of grade 1&2 (9.4%). patients over 70 years old in
grade 1&2 group presented with highest LNM rate. There is no obvious
difference among these age subgroups of grade 3. EEC G3 patients with
any of the following risk factors including LVSI, CSI, AI, or MI, the
risk of LNM would increase by 3 to 5 folds (Table 1).
After adjusted for age, parametrium involvement and tumor size in
multivariate analysis, we found LVSI, AI and CSI were independent risk
factors for LNM (Adjusted OR=3.45, 5.83, 8.93; 95% CI 1.12-10.64,
1.52-22.35, 2.85-28.00 respectively) in EEC G3 cohort. LVSI, AI, MELF,
MI (Adjusted OR=8.82, 3.40, 2.24, 5.02; 95% CI 4.88-15.96, 1.29-8.95,
1.28-3.93, 2.93-8.61, respectively) were independent risk factors among
grade 1&2 cohort (Table 3). The overall population presented with
similar trends with grade 1&2 subgroup (Adjusted OR=6.95, 3.21, 2.67,
4.30;95% CI 4.12-11.72, 1.51-6.81, 1.56-4.54, 2.66-6.94, respectively)
(Table 2). For our data, we observed tumor size increased the risk of
LNM for grade 1&2 other than grade 3.