CONCLUSIONS

In conclusion, our results show that mutations in PIK3CA gene may predict the overall survival of CRC patients, positioning PIK3CAas a potential biomarker for survival in CRC. In particular,PIK3CA exon 20 (H1047Y) mutation was associated with lower survival in CRC patients, while both exon 9 (E545K) and exon 20 (H1047Y) mutations were also associated with lower survival in patients with ECOG 0.
The PIK3CA/AKT signaling pathway could play an important role in CRC survival and should be subject of further studies in the future.