Figure legends
Fig 1. Cumulative incidence rate of ALI stratified by
on-admission LB. Shadows indicate the 95% confidence intervals of the
corresponding estimates cumulative incidence rate. ALI, acute liver
injury; LB, liver biochemistry; LBAI, liver biochemical abnormality or
injury.
Fig
2. Association between drugs and liver injury. (a) cumulative
incidence of LBAI and drugs used during the whole course. (b)cumulative incidence of ALI and drugs used during the whole course.(c) in-hospital incidence of ALI and drugs used after
admission. (d ) in-hospital worsening liver biochemistry and
drugs used after admission. Univariate model refers to univariate binary
logistic regression model. Multivariate model refers to multivariate
binary logistic regression model adjusted by age, sex, comorbidities
(defined as history of at least one disease out of hypertension,
diabetes, cardiovascular disease, cerebrovascular disease, chronic renal
disease, chronic respiratory disease and chronic liver disease),
in-hospital disease severity status, lymphocyte count, D-dimer, serum
ferritin. OR, odds ratio. CI, confidence interval. ALI, acute liver
injury; LB, liver biochemistry; LBAI, liver biochemical abnormality or
injury; Antivirus include oseltamivir, arbidol, lopinavir/ritonavir, and
some other uncommonly used antiviral drugs.
Fig 3. Cumulative incidence of in-hospital mortality of patients
with COVID-19, stratified by liver disease indicators or
hepatoprotective drugs . Shadows indicate the 95% confidence intervals
of the corresponding estimates: (a) stages of on-admission
liver injury. (b) stages of cumulative liver injury.(c) on-admission ALT. (d) on-admission AST.(e) on-admission TBIL. (f) HPD uses in patients with
abnormal liver function. LB, liver biochemistry. LBA, liver biochemical
abnormality; ALI, acute liver injury; ALT, alanine aminotransferase;
AST, aspartate aminotransferase; TBIL, total bilirubin; HPD,
hepatoprotective drugs.
Fig 4. Dynamic variations of liver biochemistry from
illness onset. Shadows indicate the 95% confidence intervals of the
corresponding estimates: (a) ALT. (b) AST.(c) TBIL. ALT, alanine aminotransferase; AST, aspartate
aminotransferase; TBIL, total bilirubin.