Cell-Type Cell-Type Percentage in Endometrium Cytokines Secreted Cytokine type (pro-/anti-inflammatory) Immunity type References
Uterine Natural killer (uNK) cells (CD3- CD56bright CD16-) Uterine Natural killer (uNK) cells (CD3- CD56bright CD16-) 70% IFNγ, TNFα, IL10, TGFβ, IL1β, CSF-1, GM-CSF Th1 & Th2 Innate [9, 29, 30, 34, 43-46]
Macrophages (CD68+) Macrophages (CD68+) 20-25% IL10, TGFβ,PGE2 Th2 Innate [27, 30, 34, 36, 58- 61]
T Lymphocytes (CD45+ CD3+ ) T Lymphocytes (CD45+ CD3+ ) 1-28% Varies - Adaptive [29-32]
CD4+T cells
Th1
3.8-21.4%
IFNγ, TNFα
Th1
Adaptive
[31, 36, 47] [32, 34,36, 47-53]
Th2 IL4 Th2
Th17 IL8 Th17
Treg IL10, TGFβ Th2
Uterine dendritic cells (Immature DCs (CD1α+) ; mature DCs (CD83+)) Uterine dendritic cells (Immature DCs (CD1α+) ; mature DCs (CD83+)) 1-2% TGF-β, IL-10 Th2 Innate [30, 36, 37-42]
B lymphocytes (CD45+ CD19+) B lymphocytes (CD45+ CD19+) 0.2-4.5% IL-10 Th2 Adaptive [ 31, 34, 35]