Toxicity - transplantation
Septicemia was observed in two of the four transplanted patients, in two patients with gram-positive pathogens, and in one patient with gram-negative pathogens. One patient had been diagnosed with biopsy-verified invasive cerebro-pulmonary mucormycosis. Viral infections were observed in all patients; two of them had infections with multiple viral pathogens, but no EBV reactivation was detected. All four transplanted patients experienced a period of profound pancytopenia. Liver toxicities noted as elevations in transaminases and/or bilirubin were observed in three of the patients, although none of them developed VOD. Grade 3 to 4 mucositis was recorded in two patients, nutritional support was required in three, one patient developed grade II hemorrhagic cystitis, and one showed sagittal sinus thrombosis probably caused by invasive fungal infection in the CNS. Acute grade I skin GvHD was diagnosed in only one patient. No chronic GvHD was observed. Toxicities are summarized in Table 4.