Toxicity - CloEC courses
The most common toxicity was profound bone marrow aplasia (grade 4 neutropenia and thrombocytopenia), observed in all patients. Microbiologically verified bacterial infections were registered in three of the seven patients after the first course of CloEC and in two out of four after the second course. One patient was diagnosed with a possible cerebro-pulmonary invasive fungal infection after the first course. Viral infections were observed in two patients after the second course (one CMV reactivation and one AdV infection). Liver toxicities were limited to transient elevation of transaminases classified as grade 4 in only one patient. No cases of VOD or hyperbilirubinemia were recorded. Only one case of mild mucositis was observed, and only one patient after each course required parenteral nutrition.