Toxicity - transplantation
Septicemia was observed in two of the four transplanted patients, in two
patients with gram-positive pathogens, and in one patient with
gram-negative pathogens. One patient had been diagnosed with
biopsy-verified invasive cerebro-pulmonary mucormycosis. Viral
infections were observed in all patients; two of them had infections
with multiple viral pathogens, but no EBV reactivation was detected. All
four transplanted patients experienced a period of profound
pancytopenia. Liver toxicities noted as elevations in transaminases
and/or bilirubin were observed in three of the patients, although none
of them developed VOD. Grade 3 to 4 mucositis was recorded in two
patients, nutritional support was required in three, one patient
developed grade II hemorrhagic cystitis, and one showed sagittal sinus
thrombosis probably caused by invasive fungal infection in the CNS.
Acute grade I skin GvHD was diagnosed in only one patient. No chronic
GvHD was observed. Toxicities are summarized in Table 4.