Patient characteristics
Among all patients enrolled, 35 (71.4%) were severe type and 14 (28.6%) were critically severe type. There were 22 (62.9%) patients with mild and 13 (37.1%) with moderate ARDS in the severe patients, 4 (28.6%) with moderate and 10 (71.4%) with severe ARDS in the critically severe patients. The clinical characteristics of patients are shown in Table 1.
There was no significant difference in age between COVID-19 pneumonia patients and healthy donors (P > 0.05). Critically severe patients had significantly higher APACHE Ⅱ score (P = 0.0001) and lower PaO2/FiO2 compared to severe patients (P < 0.0001). The HR in critically severe patients was significantly increased compared to the healthy group (P = 0.0056), and the MAP was significantly decreased than that in the healthy group and critically severe group (P < 0.01). In critically severe patients, 11 (78.6%) cases received invasive mechanical ventilation and 8 (57.1%) were treated with vasoactive drugs. There was no statistically significant difference in comorbidity between severe and critically severe patients (P > 0.05).