Results
In the current study, 39 cirrhotic patients and 41 age‐ and sex‐matched healthy participants were studied. Table 2 is a presentation of the demographic features and laboratory findings for the patients with cirrhosis and healthy subjects. Both groups were not dissimilar regarding the clinical properties. In terms of laboratory findings, white blood cell count, haemoglobin, platelet count, creatinine, sodium, and albumin were significantly decreased in the cirrhotic cases, while their alanine transaminase, aspartate transaminase, total bilirubin, indirect bilirubin, and prothrombin time were significantly elevated (p < 0.05, for each parameter). The other laboratory results were fairly similar for each group. We noted that no significant differences were present between each group in the many standard echocardiographic parameters in which the diameter and functions of the right and left spaces were evaluated (Table 3 ). However, PAS was measured as 23.62 ± 5.87 (Hz/msn) in the cirrhotic cases and 19.09 ± 4.16 (Hz/msn) in the healthy subjects (p < 0.001). Fifteen cirrhotic patients (%38.4) were clinically decompensated in the study, but there was no statistically significant dissimilarities in terms of echocardiographic parameters for compensated or decompensated cirrhotic patients (Table 4 ).
A positive statistical relevance was found between PAS and sPAP (r = 0.378; p = 0.001), and a negative statistical relevance was found with PfAT and sPAP (r = −0.314; p = 0.005). An elevated PAS values was positively associated with sPAP (p < 0.05) (Fig. 2 ). The interactions of the echocardiographic parameters with age, BMI, disease period, and PAS in cirrhotic patients are shown in Table 5 .
The independent effects of probable demographic and echocardiographic parameters associated with cirrhosis disease were evaluated by univariate and multivariate LR analysis. Following applying of the univariate analysis, five parameters were statistically significance with cirrhosis disease (sPAP, PAS, LA diameter, RV annular diameter, and E/e’); the variables, which were applied into the multivariate analysis, are shown in Table 6 . The multivariate analysis found that PAS (OR: 1.209; 95% CI: 1.059–1.381; p = 0.005), sPAP (OR: 1.201; 95% CI: 1.057–1.365; p = 0.005), and LA diameter (OR: 1.396; 95% CI: 1.079–1.805; p = 0.011) were independently linked with cirrhosis disease.