Dose Changes
The primary outcome was to determine which characteristics led to
enoxaparin dose changes in pediatric patients (Table 3). Results of the
multiple logistic regression analysis showed that patients aged 2-5.9
months (p=0.026), critical care status (p=0.009), and of Native American
ethnicity (p = 0.016) were likely to have an enoxaparin dose change at
least once during their treatment regimen guided by anti-Xa levels.
Characteristics generally thought to lead to dose changes such as age
6-11.9 months, AKI, and BMI > 95 percentile were not
statistically significant. These groups did have a smaller sample size,
therefore potentially leading to an inability to find a significant
correlation. Furthermore, the average starting dose of enoxaparin was
1.1 mg/kg/dose and the average number of dose changes were about 2 per
patient (Table 4).