4.1.1 Hysterectomy and risk of ischemic heart disease
This meta-analysis indicated that compared to non-hysterectomy, hysterectomy increased the risk of ischemic heart disease by 20%. In the results of subgroup analyses by study design, a significant association was observed in cohort studies as well as in cross-sectional studies. In the subgroup analysis of continent, hysterectomy was significantly associated with increased risk of ischemic heart disease among studies conducted in Europe and Asia.
In our research, 31% increase was found in the relationship between hysterectomy with oophorectomy and ischemic heart disease. A 33% increase in ischemic heart disease was shown in persons who underwent hysterectomy with ovarian preservation.