loading page

Association between ambient air pollution and development and persistence of atopic and non-atopic eczema in a cohort of adults
  • +13
  • Diego Lopez PeraltaOrcid,
  • caroline lodge,
  • Dinh Bui,
  • Nilakshi Waidyatillake,
  • John Su,
  • Jennifer Perret,
  • Luke Knibbs,
  • Bircan Erbas,
  • Paul Thomas,
  • Garun Hamilton,
  • Bruce Thompson,
  • Michael Abramson,
  • Haydn Walters,
  • Shyamali Dharmage,
  • Gayan Bowatte,
  • Adrian Lowe
Diego Lopez Peralta
Orcid
The University of Melbourne School of Population and Global Health
Author Profile
caroline lodge
The University of Melbourne School of Population and Global Health
Author Profile
Dinh Bui
The University of Melbourne
Author Profile
Nilakshi Waidyatillake
The University of Melbourne School of Population and Global Health
Author Profile
John Su
Monash University
Author Profile
Jennifer Perret
The University of Melbourne School of Population and Global Health
Author Profile
Luke Knibbs
The University of Queensland School of Public Health
Author Profile
Bircan Erbas
La Trobe University
Author Profile
Paul Thomas
University of New South Wales
Author Profile
Garun Hamilton
Monash University
Author Profile
Bruce Thompson
Swinburne University of Technology
Author Profile
Michael Abramson
Monash University
Author Profile
Haydn Walters
The University of Melbourne School of Population and Global Health
Author Profile
Shyamali Dharmage
The University of Melbourne School of Population and Global Health
Author Profile
Gayan Bowatte
The University of Melbourne School of Population and Global Health
Author Profile
Adrian Lowe
The University of Melbourne School of Population and Global Health
Author Profile

Peer review status:UNDER REVIEW

17 Jul 2020Submitted to Allergy
20 Jul 2020Assigned to Editor
20 Jul 2020Submission Checks Completed
23 Jul 2020Reviewer(s) Assigned

Abstract

Background: There is limited information on risk factors for eczema in adults. Recent evidence suggests that air pollution may be associated with increased incidence of eczema in adults. We aimed to assess this possible association. Methods: Ambient air pollution exposures (distance from a major road, nitrogen dioxide [NO2], fine particulate matter with an aerodynamic diameter ≤2.5 µm [PM2.5]) were assessed for the residential address of Tasmanian Longitudinal Health Study participants at ages 43 and 53 years. Eczema incidence (onset after age 43 years), prevalence (at 53 years) and persistence were assessed from surveys, while sensitisation was assessed using skin prick tests. The presence or absence of eczema and sensitisation was classified into four groups: no atopy or eczema, atopy alone, non-atopic eczema, and atopic eczema. Adjusted logistic and multinomial regression models were fitted to estimate associations between ambient air pollution and eczema, and interaction by sex was assessed. Results: Of 3153 participants in both follow ups, 2369 had valid skin prick tests. For males, a 2.3 ppb increase in baseline NO2 was associated with increased risk of prevalent eczema (OR=1.15 [95%CI 0.98-1.36]), both non-atopic (OR=1.39 [1.02-1.90]) and atopic eczema (OR=1.26 [1.00-1.59]). These associations were not seen in females (P for interaction=0.08, <0.01). For both sexes, a 1.6 µg/m3 increase in PM2.5 exposure at follow-up was associated with increased odds of aeroallergen sensitisation (OR=1.15 [1.03-1.30]). Conclusion: Increased exposure to residential ambient air pollutants was associated with an increased risk of eczema, only in males, and aeroallergen sensitisation in both genders.