Figure 6 Changes in the cytokine release profile in memory CD4+ T cells from asthmatic mice adoptively transferred with LPS-BMDCs. The schematic of the OVA-induced asthmatic mouse model is similar to that shown in Fig. 4, and memory CD4+ T cells were obtained from mouse lungs on day 40. After MLR, the level of cytokines released from memory CD4+ T cells was measured by ELISA. IL-4 secretion was reduced in both effector and central memory CD4+ T cells from mice that were adoptively transferred DClps and DC10. IFN-γ secretion was reduced in effector memory CD4+ T cells but not in central memory CD4+ T cells from mice that were adoptively transferred with DClps and DC10. (A) Th2 cytokine levels. (B) Th1 cytokine levels. The same experiment was repeated 3 times with similar results (n=5 in each group).