2.5 Risk of bias
The Risk of Bias 2.0 (RoB 2,0) tool in Review Manager 5.4 software is
used to evaluate the risk of bias27. According to
sequence generation, allocation concealment, blinding of outcome
assessors, incomplete outcome data, selective outcome reporting, and
other sources of bias, each study was determined as having a low, high,
or unclear risk of bias27. These assessments were
conducted under the guidance of the Cochrane Handbook for Systematic
Reviews of Interventions (Version 6.1.0) and the study was conducted
according to the Preferred Reporting Items for Systematic reviews and
Meta-Analyses guidelines. Two authors (J.W and L.P) independently
assessed the identified studies, the conflicts were resolved by
discussion.