3.2. Risk of Bias
The quality of the four studies was assessed as high risk, six studies
were assessed as unclear. Participants were selected, and both the
baseline and follow-up conditions are well described. Random sequence
generation was deemed to be adequate in five of the 10
trials16,18,35-37. Blinding of the outcome assessment
is unknown across five trials20,32,33,37,38. One
trial33 helped assess the high risk of bias in the
selective outcome since the pre-specified primary outcomes were not
reported. Three 33,36,37of the studies reported
conflicts of interest. The risk of bias assessment is indicated in
Figure 2a, b.