2.5 Risk of bias
The Risk of Bias 2.0 (RoB 2,0) tool in Review Manager 5.4 software is used to evaluate the risk of bias27. According to sequence generation, allocation concealment, blinding of outcome assessors, incomplete outcome data, selective outcome reporting, and other sources of bias, each study was determined as having a low, high, or unclear risk of bias27. These assessments were conducted under the guidance of the Cochrane Handbook for Systematic Reviews of Interventions (Version 6.1.0) and the study was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Two authors (J.W and L.P) independently assessed the identified studies, the conflicts were resolved by discussion.