3.9. Adverse Events
106 participants have reported 17 different adverse reactions in five of
the ten included studies20,32,34,37,38. We classified
all reported adverse reactions into three categories: gastrointestinal
symptoms, physical pain, and other adverse events (Table 2).
Gastrointestinal symptoms. Of the four studies that included
253 participants, 38 reported adverse reactions to
gastrointestinal symptoms. Among
them, 20 participants reported abdominal pain in four
studies20,32,34; five participants reported nausea in
two studies; two participants reported constipation in one
study20; one participant increased in appetite, seven
reported diarrheas in two studies18,20; one reported
an epigastric problem, and one reported flatulence in one
study20.
Physical pains . Of the three studies that included 221
participants, 43 reported adverse reactions to physical
pain18,20,34. Based on the study research on red
clover isoflavones by Lipovac et.al. (2010)18, nine
participants reported headache, 18 participants reported myalgia and 12
participants reported Arthralgia. In the study of soy isoflavones by
Rilvaet. al. (2009), two participants reported headache and one reported
pain breast. One participant reported headache with Schisandra Chinensis
treatment in Park et.al. (2016)34.
Other events. Of the three studies that included 221
participants, 23 reported adverse reactions to other events. In the
study of red clover isoflavone researched by Lipovac et.al.
(2010)18, 19 participants reported cold or upper
respiratory tract18. One participant reported tremor
of extremities, insomnia, and generalized rash in Cagnacci et.al.
(2003)20. One participant reported infection with
daidzein isoflavone in Ishiwata et.al. (2009)32.