Variables (points) Case n°1 Case n°1 Case n°2 Case n°2 Case n°2
Before CT After CT Before CT After CT Final
1) Sex, Female (+2) +2 +2 0 0 0
2) Immune disease (Thyroiditis, colitis, others) (+2) 0 0 0 0 0
3) Drugs, Positive (-4) / Negative (+1) +1 +1 +1 +1 +1
4) Alcohol, > 60 g/d (-2) / < 25 g/d (+2) +2 +2 +2 +2 +2
5) Viral markers, Negative (+3) / Positive (-3) +3 +3 +3 +3 +3
6) γ-globulin or IgG level, > 20 g/l (+3) / 15-20 g/l (2) / 10-15 g/l (+1) / <10 g/l (0) +3 +3 +3 +3 +3
7) ALP/AST, < 1,5N (+2) / 1,5-3N (0) / > 3N (-2) +2 +2 +2 +2 +2
8) ANA, SMA, anti-LKM1 titers, >1:80 (+3), 1:80 (+2), 1:40 (+1), < 1:40 (0) +3 +3 0 0 +3 (ANA)
9) AMA positive (-4) 0 0 0 0 0
10) Histological features, Interface hepatitis (+3), lymphoplasmocytaire infiltrate (1), Rosette formation (1), None of the above (-5), biliary changes (-3), Other changes (-3) NA NA NA NA NA
11) Others markers (anti-SLA, Actin, LC1, pANCA) (+2), HLA (DR3 or DR4) (+1) 0 0 0 0 +2 (anti-SLA)
12) Aggregate score without treatment, Definite AIH (>15) / Probable AIH (10 à 15) Definite (+16) + 16 Probable (+11) +11 +16
13) Treatment response, Complete (+2) / Relapse (+3) - +2 - +2 +3 (+5) +2 +3 (+5)
14) Aggregate score with treatment, Definite (>17) / Probable AIH (12-17) - Definite (+18) - Probable (+16) Definite (+21)
CT: Corticosteroid Therapy, ALP: Alkaline Phosphatase, AST: Aspartate Aminotransferase, ANA: antinuclear antibody, SMA: smooth muscle antibody, anti-LKM1: antibody to liver-kidney microsome type 1, AMA: antimitochondrial antibody, HLA: Human Leukocyte antigen, anti-SLA: antibody to soluble liver antigen, LC1: liver cytosolic antigen, pANCA: perinuclear anti-neutrophil cytoplasmic antibody , AIH: Autoimmune Hepatitis, NA: Not available CT: Corticosteroid Therapy, ALP: Alkaline Phosphatase, AST: Aspartate Aminotransferase, ANA: antinuclear antibody, SMA: smooth muscle antibody, anti-LKM1: antibody to liver-kidney microsome type 1, AMA: antimitochondrial antibody, HLA: Human Leukocyte antigen, anti-SLA: antibody to soluble liver antigen, LC1: liver cytosolic antigen, pANCA: perinuclear anti-neutrophil cytoplasmic antibody , AIH: Autoimmune Hepatitis, NA: Not available CT: Corticosteroid Therapy, ALP: Alkaline Phosphatase, AST: Aspartate Aminotransferase, ANA: antinuclear antibody, SMA: smooth muscle antibody, anti-LKM1: antibody to liver-kidney microsome type 1, AMA: antimitochondrial antibody, HLA: Human Leukocyte antigen, anti-SLA: antibody to soluble liver antigen, LC1: liver cytosolic antigen, pANCA: perinuclear anti-neutrophil cytoplasmic antibody , AIH: Autoimmune Hepatitis, NA: Not available CT: Corticosteroid Therapy, ALP: Alkaline Phosphatase, AST: Aspartate Aminotransferase, ANA: antinuclear antibody, SMA: smooth muscle antibody, anti-LKM1: antibody to liver-kidney microsome type 1, AMA: antimitochondrial antibody, HLA: Human Leukocyte antigen, anti-SLA: antibody to soluble liver antigen, LC1: liver cytosolic antigen, pANCA: perinuclear anti-neutrophil cytoplasmic antibody , AIH: Autoimmune Hepatitis, NA: Not available CT: Corticosteroid Therapy, ALP: Alkaline Phosphatase, AST: Aspartate Aminotransferase, ANA: antinuclear antibody, SMA: smooth muscle antibody, anti-LKM1: antibody to liver-kidney microsome type 1, AMA: antimitochondrial antibody, HLA: Human Leukocyte antigen, anti-SLA: antibody to soluble liver antigen, LC1: liver cytosolic antigen, pANCA: perinuclear anti-neutrophil cytoplasmic antibody , AIH: Autoimmune Hepatitis, NA: Not available CT: Corticosteroid Therapy, ALP: Alkaline Phosphatase, AST: Aspartate Aminotransferase, ANA: antinuclear antibody, SMA: smooth muscle antibody, anti-LKM1: antibody to liver-kidney microsome type 1, AMA: antimitochondrial antibody, HLA: Human Leukocyte antigen, anti-SLA: antibody to soluble liver antigen, LC1: liver cytosolic antigen, pANCA: perinuclear anti-neutrophil cytoplasmic antibody , AIH: Autoimmune Hepatitis, NA: Not available