Background and purpose
Activation of indoleamine 2,3-dioxygenase (IDO) in prefrontal cortex (PFC) is closely related to depression. It has been proved that prelimbic (PrL) and infralimbic (IL) regions of medial PFC are involved in emotion regulation, and may play distinct roles in regulation of depression. However, the mechanism of how IDO in PrL or IL affects depressive behaviors remains unclear.