Conclusions and implications
Overall, the antidepressant effects of 1-MT by inhibiting IDO in PrL or
IL are realized through different pathways, that is, by enhancing
neuroprotective effects in PrL and attenuating neurotoxic response in
IL.
Keywords: IDO, prelimbic cortex, infralimbic cortex, microglia,
astrocytes, ICV-STZ, depression
Abbreviations: IDO, indoleamine 2,3-dioxygenase; PFC,
prefrontal cortex; mPFC, medial prefrontal cortex; PrL, prelimbic
cortex; IL, infralimbic cortex; IL-6, interleukin-6; IL-1β,
interleukin-1beta; Trp, tryptophan; Kyn, kynurenine; KA, kynurenic acid;
3-HK, 3-hydroxy-kynurenine; BDNF, brain-derived neurotrophic factor;
STZ, streptozotocin; 1-MT, 1-Methyl-DL-tryptophan; Iba1, ionized
calcium-binding adaptor molecule-1; GFAP, glial fibrillary acidic
protein; GLAST, glutamate-aspartate transporter; GLT-1, glutamate
transporter-1.