Key results
Dissimilar abnormalities were observed in PrL and IL of ICV-STZ
depressed rats. In PrL, astrocyte defects were manifested, including
reduced GFAP-positive cells, glial transporters and kynurenic acid, and
morphological damage. In IL, microglial overactivation was manifested by
increased cytokines, Iba1-positive cells and 3-hydroxy-kynurenine,
accompanied by morphological alterations. Meanwhile, synaptic plasticity
was decreased in both subregions. Microinjection of 1-MT at PrL or IL
may improve depressive behaviors by reversing these different
abnormalities in PrL and IL, respectively, without influencing anxiety
behavior.