Background and purpose
Activation of indoleamine 2,3-dioxygenase (IDO) in prefrontal cortex
(PFC) is closely related to depression. It has been proved that
prelimbic (PrL) and infralimbic (IL) regions of medial PFC are involved
in emotion regulation, and may play distinct roles in regulation of
depression. However, the mechanism of how IDO in PrL or IL affects
depressive behaviors remains unclear.