Conclusions and implications
Overall, the antidepressant effects of 1-MT by inhibiting IDO in PrL or IL are realized through different pathways, that is, by enhancing neuroprotective effects in PrL and attenuating neurotoxic response in IL.
Keywords: IDO, prelimbic cortex, infralimbic cortex, microglia, astrocytes, ICV-STZ, depression
Abbreviations: IDO, indoleamine 2,3-dioxygenase; PFC, prefrontal cortex; mPFC, medial prefrontal cortex; PrL, prelimbic cortex; IL, infralimbic cortex; IL-6, interleukin-6; IL-1β, interleukin-1beta; Trp, tryptophan; Kyn, kynurenine; KA, kynurenic acid; 3-HK, 3-hydroxy-kynurenine; BDNF, brain-derived neurotrophic factor; STZ, streptozotocin; 1-MT, 1-Methyl-DL-tryptophan; Iba1, ionized calcium-binding adaptor molecule-1; GFAP, glial fibrillary acidic protein; GLAST, glutamate-aspartate transporter; GLT-1, glutamate transporter-1.