Conclusion
This study proposes a conceptual model linking psychosocial stress
during the prenatal and postnatal periods to respiratory problems in
children, testing the model with prospective evidence. The supported
mechanisms through which perinatal stress exposure contributes to
childhood wheeze include LTRI and SSE. These findings represent a step
toward better understanding of early-life origins of wheezing though the
exact aetiology remains unknown. More precise identification of sources
of respiratory health risks in children can inform early preventive
efforts targeting women and children at risk during critical periods of
development.
The authors of this study wish to thank the participating families as
well as the gynaecologists, paediatricians, school heads, and class
teachers who took part in the project. Our thanks also go to Dr. Lubomír
Kukla, Ph.D., ELSPAC national coordinator 1990–2012, and the entire
ELSPAC team. The authors of this study (i.e. not the ELSPAC Scientific
Council) are responsible for the contents of this publication.
Dr. Stepanikova has nothing to disclose. Dr. Mikes has nothing to
disclose. Dr. Thon has nothing to disclose. Dr. Klanova has nothing to
disclose.
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