Aims The study was to investigate the effects of Intravenous Nicorandil on blood pressure and drug safety in patients with coronary heart disease. Methods In order to evaluate the blood pressure lowering effects and safety of Intravenous Nicorandil, we recruited 43 inpatients with unstable angina to intravenously pump Nicorandil, and the pumping speeds (2mg/h, 4mg/h and 6mg/h, respectively) were adjusted according to the patient’s blood pressure. After treatment, the effects of Intravenous Nicorandil on blood pressure and drug safety were observed. Results After treatment, the average reduction in SBP was 22.86±19.83mmHg，and the average reduction in DBP was 9.80±18.58mmHg. And Nicorandil could decrease patients blood pressure in a concentration-dependent manner. During the following-up, no serious adverse events were observed. Conclusion Intravenous Nicorandil could significantly reduce systolic and diastolic blood pressure in patients without affecting heart rate, and it reduced in depending on concentrations, suggesting that Intravenous Nicorandil may be a new intravenous antihypertensive drug in future clinical application.