Efficacy and Safety of Intravenous Nicorandil on blood pressure in
patients with coronary heart disease Corresponging author: Yan He, Email
Aims The study was to investigate the effects of Intravenous Nicorandil
on blood pressure and drug safety in patients with coronary heart
disease. Methods In order to evaluate the blood pressure lowering
effects and safety of Intravenous Nicorandil, we recruited 43 inpatients
with unstable angina to intravenously pump Nicorandil, and the pumping
speeds (2mg/h, 4mg/h and 6mg/h, respectively) were adjusted according to
the patient’s blood pressure. After treatment, the effects of
Intravenous Nicorandil on blood pressure and drug safety were observed.
Results After treatment, the average reduction in SBP was
22.86±19.83mmHg，and the average reduction in DBP was 9.80±18.58mmHg.
And Nicorandil could decrease patients blood pressure in a
concentration-dependent manner. During the following-up, no serious
adverse events were observed. Conclusion Intravenous Nicorandil could
significantly reduce systolic and diastolic blood pressure in patients
without affecting heart rate, and it reduced in depending on
concentrations, suggesting that Intravenous Nicorandil may be a new
intravenous antihypertensive drug in future clinical application.