Moreover, Figure 2 shows the main reactions in the photosensitizing capacity of AMP in lipid media. In this, two cyclic routes could be observed. In the first1AMP→AMP*→AMP•−1AMP and in the second1AMP→1AMP*→3AMP→AMP•+1AMP found, both reaction routes carried out the regeneration of AMP in lipid media. According to the above, AMP can yield ROS by a cyclic path of reactions in lipid media and produce oxidative stress.
Figure 2. Reactions involved in the photosensitizing capability of AMP in lipid media.
In summary, the results concerning the photosensitizing capability of AMP showed that the main differences between AMP and their derivatives are in the electronic conjugation of their double bonds; hence, the photosensitizing property of AMP could be attributed to the presence of electronic conjugation of their double bonds. Consequently, we might propose that amphotericin B can possess the pro-oxidant capability in lipid media, through the photosensitizing property. In the same way, amphotericin B can produce ROS by a cyclic reaction that could regenerate amphotericin B. Therefore, this study supports the pro-oxidant capability of amphotericin B in lipid media and contributes to knowledge about the primary mechanism involved in its antibiotic property.