Results and discussion
The study on the pro-oxidant capability of AMP was carried out through
the calculation of excitation energies. The results calculated show that
AMP has a maximum wavelength of 399.32 nm in pentylethanoate and this
result was corroborated with the experimental results, where the maximum
wavelength for amphotericin B was 408 nm in a non-polar
media.39
Additionally, the main characteristic bond distances of AMP and its
reaction intermediates such as 1AMP,1AMP*, 3AMP, AMP•−and AMP•+, are shown in Table 1, as well as the
numbering of atoms are shown in Figure 1. In these were observed that
C20-C21, C22-C23, C24-C25, C26-C27, C28-C29, C30- C31, and C32-C33 bond
distances are larger in the 1AMP*,3AMP, AMP•− and
AMP•+ species than 1AMP. It was also
observed that the largest bond corresponds to the 3AMP
molecule. A decrease in bond distances C21-C22, C23-C24, C25-C26,
C27-C28, C29-C30, and C31-C32 were seen in 1AMP*,3AMP, AMP•− and
AMP•+ when compared with the 1AMP.
The species that showed the shortest bond distance is3AMP.
Table 1 . Bond distances in angstroms from AMP and their
reaction intermediates in lipid media, at 298 K.