Moreover,
Figure 2 shows the main reactions in the photosensitizing capacity of
AMP in lipid media. In this, two cyclic routes could be observed. In the
first1AMP→AMP*→AMP•−→1AMP
and in the second1AMP→1AMP*→3AMP→AMP•+→1AMP
found, both reaction routes carried out the regeneration of AMP in lipid
media. According to the above, AMP can yield ROS by a cyclic path of
reactions in lipid media and produce oxidative stress.
Figure 2. Reactions involved in the photosensitizing capability
of AMP in lipid media.
In summary, the results concerning the photosensitizing capability of
AMP showed that the main differences between AMP and their derivatives
are in the electronic conjugation of their double bonds; hence, the
photosensitizing property of AMP could be attributed to the presence of
electronic conjugation of their double bonds. Consequently, we might
propose that amphotericin B can possess the pro-oxidant capability in
lipid media, through the photosensitizing property. In the same way,
amphotericin B can produce ROS by a cyclic reaction that could
regenerate amphotericin B. Therefore, this study supports the
pro-oxidant capability of amphotericin B in lipid media and contributes
to knowledge about the primary mechanism involved in its antibiotic
property.