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Lactobacillus fermentum CECT5716 ameliorates high fat diet-induced obesity in mice through modulation of gut microbiota dysbiosis.
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  • Jose Alberto Molina-Tijeras,
  • Patricia Diez-Echave,
  • Teresa Vezza,
  • Laura Hidalgo Garcia,
  • Antonio Jesús Ruiz-Malagón,
  • Maria Jesús Rodríguez-Sojo,
  • Miguel Romero,
  • Iñaki Robles-Vera,
  • Federico Garcia,
  • Julio Plaza-DiazOrcid,
  • Mónica Olivares,
  • Juan Duarte,
  • Maria Elena Rodriguez-Cabezas,
  • Alba Rodríguez-Nogales,
  • Julio Galvez
Jose Alberto Molina-Tijeras
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Patricia Diez-Echave
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Teresa Vezza
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Laura Hidalgo Garcia
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Antonio Jesús Ruiz-Malagón
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Maria Jesús Rodríguez-Sojo
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Miguel Romero
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
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Iñaki Robles-Vera
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
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Federico Garcia
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
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Julio Plaza-Diaz
Orcid
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
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Mónica Olivares
Biosearch Life
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Juan Duarte
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
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Maria Elena Rodriguez-Cabezas
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Alba Rodríguez-Nogales
1 CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Julio Galvez
CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada
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Abstract

Background and Purpose: Obesity is a complex condition where a low-grade chronic inflammation and gut dysbiosis contribute to the development of the related metabolic dysfunctions. Nowadays, its management of such disease implies drastic changes in lifestyle and different anti-obesity drugs. Unfortunately, most of them present limited effectiveness and important side effects. Therefore there is an urgent demand for more effective and safer strategies for obesity management. In this sense, probiotics are emerging as a promising therapy. Different probiotics have demonstrated beneficial effects on this condition, increasing the interest in the development of probiotic treatments. Lactobacillus fermentum CECT5716 has shown anti-inflammatory effects and capacity to modulate microbiota composition in different experimental models. Experimental Approach: L. fermentum CECT5716 (5x108 CFU/mice/day) was evaluated in a model of high fat diet-induced obesity in mice. Key results: L. fermentum exerts anti-obesity effects, associated with its anti-inflammatory properties and amelioration endothelial dysfunction and gut dysbiosis. The probiotic restores Akkermansia sp. abundance and reduced Erysipelotrichi class and Clostridium spp presence as well as increased Bacteroides proportion. Conclusion and Implications: This probiotic represents a very interesting approach. Our findings describe, for the first time, the ability of this probiotic to ameliorate experimental obesity through microbiome modulation, affecting different bacteria that have been reported to play a key role in the pathogenesis of obesity. Therefore, this suggests a potential use of L. fermentum CECT5716 in clinical practice, also taking into account that probiotic treatments have demonstrated to be relatively safe and well tolerated.