Propensity score
Propensity score-matched method was applied to balance the confounding
factors between two groups. The selected variables to be potential
confounders associated with clinical outcomes were age, gender, BMI,
hypertension (HT), diabetes mellitus (DM), stroke, smoker, CKD, LDL,
HDL, TC and TG. The PCSK-9 inhibitor group and statins therapies groups
were paired at 1:1 using nearest matching with a caliper size of 0.05.
We adjusted for imbalanced variables past history (MI, PCI, and CABG),
diagnose (stable angina, unstable angina, NSTEMI, STEMI and ischemic
cardiomyopathy) following mixed-effect Cox model.