Measures of treatment outcomes
The targeted lipid control rates were considered as LDL-C levels goals
under 1.0mmol/L or 1.4mmol/L. Cardiovascular events were defined as a
total of death, MI, TVR, re-angina and re-hospitalization for cardiac
events. Death was considered to be of cardiac origin unless an alternate
cause was unequivocally established, even in participants with serious
non-cardiac comorbidities. Spontaneous MI was defined as the presence of
clinical or electrocardiographic changes consistent with myocardial
ischemia and circulating cardiac biomarker concentrations above the
upper limit of normal, in accordance with the universal definition
[12]. TVR was defined as the requirement for a repeated percutaneous
intervention or surgical bypass of any segment of a target vessel. A
target vessel was defined as the entire major coronary vessel proximal
and distal to the target lesion, which included the upstream and
downstream branches and the target lesion itself.