1.1. Prevalence of Haemophilia in EU
In order to obtain prevalence information for individuals living with
haemophilia A and B in Europe, relevant information from the World
Federation of Haemophilia (WFH) annual global surveys and the literature
were reviewed. To estimate the prevalence of haemophilia throughout
Europe, in general, the WFH 2018 survey was utilized [1]. For
countries where prevalence was not available from the 2018 survey, the
most recent version of the WFH report that contained the relevant data
was used.
Table 1 presents data of the haemophilia A and B prevalence for the
European countries who reported data to the WFH. According to the
consolidated WFH survey data, the prevalence among European countries
ranged from 0.27 per 10,000 males in Finland to 1.38 per 10,000 males in
Ireland for Haemophilia A and 0.06 per 10.000 males in Finland to 0.51
per 10.000 in Ireland.
In a recent meta-analysis [7] it was shown that more than 1,125,000
men around the world have an inherited bleeding disorder; 418,000 of
those have a severe version of haemophilia. Previously, only 400,000
people globally were estimated to have haemophilia. The results proposed
an estimate of 2.46 cases per 10.000 males for all severities of
haemophilia A and 0.5 cases per 10.000 males for all severities of
haemophilia B. Applying a prevalence of 2.96 cases per 10.000 males for
haemophilia A and B combined to the current European population estimate
of 517 million (248 million males) (retrieved fromhttps://ec.europa.eu/eurostat/data/database , accessed in June
2020) generates an estimate of 73.408 males with haemophilia in EU, of
whom about 16,120 should have severe haemophilia. These estimates are
higher than those historically cited but still characterize haemophilia
as rare diseases on the basis of definitions used in European Union
(<5 cases per 10 000 persons Regulation (EC) No. 141/2000 of
the European Parliament and of the Council) [2].