A Natural History Study of Nitrous Oxide versus Propofol-Assisted Intrathecal Therapy in the Treatment of Acute Lymphoblastic Leukemia

Lane H Miller MD MSc¹, Stuart S Winter MD¹, Dave Watson PhD², Mylynda Livingston CNP¹, Resty Nemata³, and Yoav Messinger MD¹

From the Cancer and Blood Disorders,¹ the Design and Analytics Programs,² and ITS Data Systems³, Children’s Minnesota, Minneapolis, MN 55404

Address correspondence to:

Lane Miller, MD MSc

Cancer and Blood Disorders Program

2525 Chicago Avenue South

Minneapolis, MN 55404

lane.miller@childrensmn.org

Abstract word count: 249

Main text word count: 1870

Number of tables: 3

Number of figures: 2

Running title: Nitrous oxide versus propofol-assisted intrathecal therapy in ALL

Keywords: leukemia, pediatric, sedation, lumbar puncture, intrathecal, supportive care

Meeting abstracts:

Miller LH, Winter S, Watson D, Livingston M, Messinger Y. (2021) Comparing effectiveness of nitrous oxide and propofol-assisted lumbar punctures in childhood acute lymphoblastic leukemia. Oral presentation at the Children’s Remarkable Research Conference, May 2021.

Miller LH, Livingston M, Watson D, Winter S, Messinger Y. (2020) Comparing effectiveness of nitrous oxide, propofol, and midazolam-assisted lumbar punctures in childhood acute lymphoblastic leukemia. Poster at the American Society of Hematology Annual Meeting, December 2020.

Miller LH, Finch M, Livingston M, Winter S, Messinger Y. (2020) Comparing effectiveness and safety of nitrous oxide versus propofol-assisted sedation for lumbar punctures in childhood acute lymphoblastic leukemia. Poster at the American Society of Pediatric Hematology and Oncology Annual Meeting, May 2020.

Abbreviation Key: