Study population:
Inclusion criteria were ICU admitted adult patients with a confirmed ARC by 12-hour urine collection (12-hr CrCl ≥130 ml/min/1.73 m2) who received meropenem 1g or 2g every 8 hours, as an intermittent infusion over 4-hr, according to physician decision. Patients who were pregnant or lactating, or had a Serum Creatinine (Scr) ≥ 1.3 mg/dL and hypersensitivity to β -lactams were excluded.