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A multicenter study of viral aetiology of Community-Acquired Pneumonia in hospitalized children in mainland China
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  • Yun Zhu,
  • Baoping Xu,
  • Changchong Li,
  • Zhimin Chen,
  • Ling Cao,
  • Zhou Fu,
  • Yunxiao Shang,
  • Aihuan Chen,
  • Li Deng,
  • Yixiao Bao,
  • Yun Sun,
  • Limin Ning,
  • Shuilian Yu,
  • Fang Gu,
  • Adong Shen,
  • Ju Yin,
  • Chunyan Liu,
  • Zhengde Xie,
  • Kunling Shen
Yun Zhu
Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health
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Baoping Xu
Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health
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Changchong Li
The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
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Zhimin Chen
The Children's Hospital-Zhejiang University School of Medical
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Ling Cao
Children's Hospital Capital Institute of Pediatrics
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Zhou Fu
Children's Hospital of Chongqing Medical University
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Yunxiao Shang
Shengjing Hospital of China Medical University
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Aihuan Chen
The First Affiliated Hospital of Guangzhou Medical University
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Li Deng
Guangzhou Women and Children's Medical Center
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Yixiao Bao
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
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Yun Sun
Yinchuan women and children healthcare hospital
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Limin Ning
Children’s Hospital of Changchun
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Shuilian Yu
The 2nd Affiliated Hospital of Harbin Medical University
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Fang Gu
Baoding Children’s Hospital
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Adong Shen
Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health
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Ju Yin
Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health
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Chunyan Liu
Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health
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Zhengde Xie
Beijing Children's Hospital
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Kunling Shen
Beijing Children's Hospital
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Abstract

Background Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality in the children worldwide. In this study, we aim to describe the aetiology of viral infection of pediatric community-acquired pneumonia in mainland China. Methods During Nov. 2014 and Jun. 2016, the prospective study was conducted at thirteen hospitals. The hospitalized children under 18 years old who met the criteria for CAP were enrolled. The throat swabs or nasopharyngeal aspirates were collected from cases and screened the eighteen respiratory viruses using multiplex PCR assay. Results Viral pathogens were present in 56.6% (1539/2721) of enrolled cases, with the detection rate of single virus in 39.8% cases and multiple viruses in 16.8% cases. The most frequently detected virus was RSV (15.2%, 413/2721). The highest detection rate of virus was in < 6 m age group (70.7%). RSV, HMPV, HPIVs and Flu B showed the similar prevalence pattern both in northern and south China, but HPIVs, Flu A, HBoV, HAdV and HCoVs showed the distinct circulating patterns in northern and south China. HEV/HRV (27.6%, 27/98), HBoV (18.4%, 18/98), RSV (16.3%, 16/98) and HMPV (14.3%, 14/98) were the most commonly detected virus in severe pneumonia children with signal virus infection. Conclusions In conclusion, viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP. RSV was the most important virus in hospitalized children with CAP in mainland China.