Proximal Factors
Child TB Disease
There were 242 (20%) of children with confirmed PTB, 560 (47%) with unconfirmed TB and 400 (33%) with unlikely TB. Overall, n=756 (63%) of children were started on TB treatment [Table I]. Treated PTB was associated with the following child characteristics in univariate analyses: male (p = 0.004), previous hospitalization (p <0.001), lower weight-for-age z score (p = 0.001), lower height-for-age z score (p<=0.003) [Table III]. Previous TB treatment was found to be protective against being started on TB treatment (p = 0.028). In the multivariate analysis, male gender (p=.0004) and previous hospitalization (p<0.001) remained significantly associated with treated PTB as proximal factors.
Adherence to the 3-month follow-up visit
Of the 1,202 children whose caregiver completed the psychosocial questionnaire at baseline, 6 (0.5%) children died before the 3-month visit, and 27 (2%) were disenrolled due to relocation. Overall, adherence in this study was high, approaching 94%. Of the remaining 1,169, 6% did not attend the 3-month visit and were considered lost-to-follow-up (LFTU) [Table I]. LTFU was associated with children with severe stunting (p=0.017), hospitalization (p<0.001), caregiver smoking (p= 0.009) or severe psychological distress as assessed based on the Kesler 10 questionnaire administered to the caregiver questionnaire (p=0.019) in univariate analyses. In a multivariate logistic regression model, severe stunting was independently associated with non-adherence to the three-month follow-up visit [Supplemental Table VI].