Human subjects
This study was approved by the Ethics Committee of the University Hospital Germans Trias i Pujol and was performed in accordance with the Declaration of Helsinki for Human Research. Written informed consent was obtained from all participants. Muscle biopsies were obtained from the biceps brachii of five patients with confirmed DM1. For comparison, we included as controls non-DM1 patients of the traumatology department, who needed to undergo minor surgeries. Patients and controls were age and sex-matched. We recorded clinical data for each DM1 patient, including MIRS, MRC, 6MWD and mRS, the latter rates global disability and is mostly used for strokes, even though it can be applied to other causes of neurological impairment.