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Oncofertility treatment of adult granulosa cell tumor in adolescent with risk of thromboembolic event
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  • Dražan Butorac,
  • Ana-Meyra Potkonjak,
  • Meri Margreitner,
  • Marina Kos,
  • Gorana Mirošević
Dražan Butorac
Klinička Bolnica Sestre Milosrdnice
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Ana-Meyra Potkonjak
Klinička Bolnica Sestre Milosrdnice
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Meri Margreitner
Health Centre Zagreb East
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Marina Kos
Klinička Bolnica Sestre Milosrdnice
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Gorana Mirošević
Klinička Bolnica Sestre Milosrdnice
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Abstract

Adult granulosa cell tumor is predominant form of granulosa cell tumor, typically diagnosed after the age of 40 years. We report a case of a 16-year-old girl with an AGCT who presented with raised testosterone levels. After fertility sparing surgery, patient was commenced on combined oral contraceptives (COCs) due to the menstrual cycle irregularities. Subsequently, patient’s father developed pulmonary embolism caused by venous thromboembolism. Hematologic evaluation in our patient, revealed decreased protein S levels. Nevertheless, COCs were continued for up to the six months. Since menstrual cycles irregularities reoccurred, we are starting with progesterone-only oral contraceptives at present time.