aThis work, bFrom Ref [43],cFrom Ref [46], dFrom Ref
[42], eFrom Ref [45], fFrom
Ref [44], gFrom Ref [47].
B3LYP/6-31G* calculations performed for the S(-) form of CQ predict a
ΔGc value of -52.06 kJ/mol [46]. The graphics of
total acceptors and donors H bonds groups for antiviral agents versus
the ΔGc values by using B3LYP/6-31G* calculations
generate an approximate lineal correlation with a correlation
coefficient of R² = 0.8691 while when the values of both forms of CQ are
considered the lineal correlation coefficient increases at R² = 0.9096.
Note that the higher ΔGc values in the antiviral agents
are observed when the total acceptor and donors H bonds groups increase
to 19, as it was observed in brincidofovir and in the hydrated foscarnet
salt [44,45].