Metabolic pathway characterized by pure human CYP enzyme
IVM metabolites M1, M3, M5, M6, M7, M8, M9, M10, and M12 were all found after 60 minutes of incubation with CYP3A4. IVM metabolite M1 was also produced by CYP3A5. M13 was produced by CYP2C8. None of the other investigated enzymes produced detectable amounts of the identified IVM metabolites. Proposed metabolite pathways are shown in Figure 7.