|
|
|
|
Risk with [PLACEBO] |
Risk difference with
[GKAs] |
FPG (FPG) |
355
(5 RCTs)
|
⨁⨁⨁◯
MODERATE a
|
- |
The mean FPG was 0 SD |
MD 0.71 SD
lower
(1.11 lower to 0.31 lower)
|
HbA1c |
370
(4 RCTs)
|
⨁⨁⨁◯
MODERATE a
|
- |
The mean hbA1c was 0 SD |
MD 0.65
SD lower
(0.82 lower to 0.48 lower)
|
Total AEs |
605
(4 RCTs)
|
⨁⨁⨁◯
MODERATE a
|
RR 1.11
(0.95 to 1.30)
|
482
per 1,000 |
53 more per
1,000
(24 fewer to 145 more)
|
Hypoglycemia |
840
(5 RCTs)
|
⨁⨁⨁◯
MODERATE a
|
RR 1.81
(1.35 to 2.42)
|
109
per 1,000 |
89 more per
1,000
(38 more to 155 more)
|
Headache |
501
(3 RCTs)
|
⨁⨁⨁◯
MODERATE a
|
RR 1.30
(0.49 to 3.43)
|
28
per 1,000 |
8 more per
1,000
(14 fewer to 68 more)
|
Diarrhea |
501
(3 RCTs)
|
⨁⨁⨁◯
MODERATE a
|
RR 1.64
(0.69 to 3.87)
|
32
per 1,000 |
20 more per
1,000
(10 fewer to 92 more)
|
Nausea |
267
(2 RCTs)
|
⨁⨁⨁◯
MODERATE a
|
RR 2.65
(0.53 to 13.26)
|
15
per 1,000 |
24 more per
1,000
(7 fewer to 182 more)
|
*The risk in the intervention group (and its
95% confidence interval) is based on the assumed risk in the comparison
group and the relative effect of the intervention (and its 95%
CI).
CI: Confidence interval; MD: Mean
difference; RR: Risk ratio
|
*The
risk in the intervention group (and its 95% confidence interval) is
based on the assumed risk in the comparison group and the
relative effect of the intervention (and its 95%
CI).
CI: Confidence interval; MD: Mean
difference; RR: Risk ratio
|
*The
risk in the intervention group (and its 95% confidence interval) is
based on the assumed risk in the comparison group and the
relative effect of the intervention (and its 95%
CI).
CI: Confidence interval; MD: Mean
difference; RR: Risk ratio
|
*The
risk in the intervention group (and its 95% confidence interval) is
based on the assumed risk in the comparison group and the
relative effect of the intervention (and its 95%
CI).
CI: Confidence interval; MD: Mean
difference; RR: Risk ratio
|
*The
risk in the intervention group (and its 95% confidence interval) is
based on the assumed risk in the comparison group and the
relative effect of the intervention (and its 95%
CI).
CI: Confidence interval; MD: Mean
difference; RR: Risk ratio
|
*The
risk in the intervention group (and its 95% confidence interval) is
based on the assumed risk in the comparison group and the
relative effect of the intervention (and its 95%
CI).
CI: Confidence interval; MD: Mean
difference; RR: Risk ratio
|
GRADE Working Group grades of
evidence
High certainty: We are very confident
that the true effect lies close to that of the estimate of the
effect
Moderate certainty: We are moderately
confident in the effect estimate: The true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different
Low certainty: Our
confidence in the effect estimate is limited: The true effect may be
substantially different from the estimate of the
effect
Very low certainty: We have very little
confidence in the effect estimate: The true effect is likely to be
substantially different from the estimate of effect 11a. The
category and dose of GKAs varied in all the trials.
|
GRADE Working Group grades of
evidence
High certainty: We are very confident
that the true effect lies close to that of the estimate of the
effect
Moderate certainty: We are moderately
confident in the effect estimate: The true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different
Low certainty: Our
confidence in the effect estimate is limited: The true effect may be
substantially different from the estimate of the
effect
Very low certainty: We have very little
confidence in the effect estimate: The true effect is likely to be
substantially different from the estimate of effect 22a. The
category and dose of GKAs varied in all the trials.
|
GRADE Working Group grades of
evidence
High certainty: We are very confident
that the true effect lies close to that of the estimate of the
effect
Moderate certainty: We are moderately
confident in the effect estimate: The true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different
Low certainty: Our
confidence in the effect estimate is limited: The true effect may be
substantially different from the estimate of the
effect
Very low certainty: We have very little
confidence in the effect estimate: The true effect is likely to be
substantially different from the estimate of effect 33a. The
category and dose of GKAs varied in all the trials.
|
GRADE Working Group grades of
evidence
High certainty: We are very confident
that the true effect lies close to that of the estimate of the
effect
Moderate certainty: We are moderately
confident in the effect estimate: The true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different
Low certainty: Our
confidence in the effect estimate is limited: The true effect may be
substantially different from the estimate of the
effect
Very low certainty: We have very little
confidence in the effect estimate: The true effect is likely to be
substantially different from the estimate of effect 44a. The
category and dose of GKAs varied in all the trials.
|
GRADE Working Group grades of
evidence
High certainty: We are very confident
that the true effect lies close to that of the estimate of the
effect
Moderate certainty: We are moderately
confident in the effect estimate: The true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different
Low certainty: Our
confidence in the effect estimate is limited: The true effect may be
substantially different from the estimate of the
effect
Very low certainty: We have very little
confidence in the effect estimate: The true effect is likely to be
substantially different from the estimate of effect 55a. The
category and dose of GKAs varied in all the trials.
|
GRADE Working Group grades of
evidence
High certainty: We are very confident
that the true effect lies close to that of the estimate of the
effect
Moderate certainty: We are moderately
confident in the effect estimate: The true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different
Low certainty: Our
confidence in the effect estimate is limited: The true effect may be
substantially different from the estimate of the
effect
Very low certainty: We have very little
confidence in the effect estimate: The true effect is likely to be
substantially different from the estimate of effect 66a. The
category and dose of GKAs varied in all the trials.
|