Statistical analysis
Statistical analysis was conducted with SPSS Ver. 17.0 (SPSS, Chicago, IL). Continuous variables were presented as mean and SD or SEM, and compared by Student’s ttest, paired t test or analysis of variance (ANOVA) with post hoc least-significant differencest test. Categorical variables were presented as percentages, and compared by χ2 test with Bonferroni correction when appropriate. Multivariable Logistic regression was used to analyze the relationship between SNPs and endpoint events in different populations; the degree of association was expressed by odds ratio (OR) and 95% confidence interval (CI); The interaction between gene polymorphism and risk factors was substituted into the equation. Hardy-Weinberg equilibrium for rs3801150 was tested using χ2 goodness-of-fit test. P values were two-tailed and considered significant when less than 0.05.