References
  1. CORNIER M A, DABELEA D, HERNANDEZ T L, et al. The metabolic syndrome [J]. Endocrine reviews, 2008, 29(7): 777-822.
  2. XI B, HE D, HU Y, et al. Prevalence of metabolic syndrome and its influencing factors among the Chinese adults: the China Health and Nutrition Survey in 2009 [J]. Preventive medicine, 2013, 57(6): 867-871.
  3. FORD E S, LI C, SATTAR N. Metabolic syndrome and incident diabetes: current state of the evidence [J]. Diabetes care, 2008, 31(9): 1898-1904.
  4. GAMI A S, WITT B J, HOWARD D E, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies [J]. Journal of the American College of Cardiology, 2007, 49(4): 403-414.
  5. MOTTILLO S, FILION K B, GENEST J, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis [J]. Journal of the American College of Cardiology, 2010, 56(14): 1113-1132.
  6. RODRIGUEZ-COLON S M, MO J, DUAN Y, et al. Metabolic syndrome clusters and the risk of incident stroke: the atherosclerosis risk in communities (ARIC) study [J]. Stroke; a journal of cerebral circulation, 2009, 40(1): 200-205.
  7. GRUNDY S M, HANSEN B, SMITH S C, JR., et al. Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management [J]. Circulation, 2004, 109(4): 551-556.
  8. GROOP L. Genetics of the metabolic syndrome [J]. The British journal of nutrition, 2000, 83 Suppl 1(S39-48).
  9. LI J K, NG M C, SO W Y, et al. Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus [J]. Diabetes/metabolism research and reviews, 2006, 22(1): 46-52.
  10. SHAFIU M, JOHNSON R J, TURNER S T, et al. Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension [J]. Kidney & blood pressure research, 2012, 35(6): 477-482.
  11. BURGUETE GARCIA A I, MARTINEZ NAVA G A, VALLADARES SALGADO A, et al. Association of beta1 and beta3 adrenergic receptors gene polymorphisms with insulin resistance and high lipid profiles related to type 2 diabetes and metabolic syndrome [J]. Nutricion hospitalaria, 2014, 29(6): 1327-1334.
  12. RHIE Y J, CHOI B M, EUN S H, et al. Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents [J]. Journal of Korean medical science, 2011, 26(6): 797-802.
  13. YANG Q, ESKURZA I, KIERNAN U A, et al. Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay [J]. Endocrinology, 2012, 153(3): 1519-1527.
  14. KADOMATSU T, TABATA M, OIKE Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases [J]. The FEBS journal, 2011, 278(4): 559-564.
  15. TAM C H, MA R C, SO W Y, et al. Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents [J]. Diabetes, 2009, 58(3): 765-769.
  16. NUSING R, SCHNEIDER-VOSS S, ULLRICH V. Immunoaffinity purification of human thromboxane synthase [J]. Archives of biochemistry and biophysics, 1990, 280(2): 325-330.
  17. NELSON D R, KAMATAKI T, WAXMAN D J, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature [J]. DNA and cell biology, 1993, 12(1): 1-51.
  18. HIRATA M, HAYASHI Y, USHIKUBI F, et al. Cloning and expression of cDNA for a human thromboxane A2 receptor [J]. Nature, 1991, 349(6310): 617-620.
  19. TANABE T, YOKOYAMA C, MIYATA A, et al. Molecular cloning and expression of human thromboxane synthase [J]. Journal of lipid mediators, 1993, 6(1-3): 139-144.
  20. CHASE M B, BAEK S J, PURTELL D C, et al. Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization [J]. Genomics, 1993, 16(3): 771-773.
  21. MIYATA A, YOKOYAMA C, IHARA H, et al. Characterization of the human gene (TBXAS1) encoding thromboxane synthase [J]. European journal of biochemistry / FEBS, 1994, 224(2): 273-279.
  22. YOKOYAMA C, MIYATA A, IHARA H, et al. Molecular cloning of human platelet thromboxane A synthase [J]. Biochemical and biophysical research communications, 1991, 178(3): 1479-1484.
  23. OH S H, KIM Y H, PARK S M, et al. Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients [J]. Pharmacogenomics, 2011, 12(3): 351-363.
  24. LEMAITRE R N, RICE K, MARCIANTE K, et al. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke [J]. Atherosclerosis, 2009, 204(2): e58-63.
  25. ALBERTI K G, ECKEL R H, GRUNDY S M, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J]. Circulation, 2009, 120(16): 1640-1645.
  26. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005; 21:263–265.
  27. ULRICH C M, CARLSON C S, SIBERT J, et al. Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure [J]. Human mutation, 2005, 26(4): 394-395.
  28. ABRAHAM J E, HARRINGTON P, DRIVER K E, et al. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival [J]. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, 15(6): 2181-2191.
  29. PARK S A, PARK B L, PARK J H, et al. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population [J]. BMB reports, 2009, 42(4): 200-205.
  30. Ramazi S1, Heydari-Zarnagh H2, Goudarzian M3, et al. Thromboxane A synthase 1 gene expression and promotor haplotypes are associated with risk of large artery-atherosclerosis stroke in Iranian population [J]. J Cell Biochem. 2019, 120(9):15222-15232.
  31. Li L, He ZY, Wang YZ, et al. Associations between thromboxane A synthase 1 gene polymorphisms and the risk of ischemic stroke in a Chinese Han population [J]. Neural Regen Res. 2018, 13(3):463-469.
  32. VAN ROOY M J, PRETORIUS E. Obesity, hypertension and hypercholesterolemia as risk factors for atherosclerosis leading to ischemic events [J]. Current medicinal chemistry, 2014, 21(19): 2121-2129.
Figure legends
Figure 1. Disposition of Subjects