Statistical analysis
Statistical analysis was conducted with SPSS Ver. 17.0 (SPSS, Chicago,
IL). Continuous variables were presented as mean and SD or SEM, and
compared by Student’s ttest, paired t test or
analysis of variance (ANOVA) with post hoc least-significant differencest test. Categorical variables were presented as percentages, and
compared by χ2 test with Bonferroni correction when appropriate.
Multivariable Logistic regression was used to analyze the relationship
between SNPs and endpoint events in different populations; the degree of
association was expressed by odds ratio (OR) and 95% confidence
interval (CI); The interaction between gene polymorphism and risk
factors was substituted into the equation. Hardy-Weinberg equilibrium
for rs3801150 was tested using χ2 goodness-of-fit test. P values
were two-tailed and considered significant when less than 0.05.