Neurologic Deficits Involving Both Upper and Lower Motor
Neurons
One of the clues to a diagnosis of ALS is the involvement of both upper
and lower motor neurons. There is an insidious progression along the
neuraxis. The pathology of trichothecenes could explain this pattern.
Marcesca, M. 201330 reports on the transport of
food-associated trichothecenes from the gut to the brain. The ready
movement of T-2 toxin across the blood brain barrier leads to its
accumulation in the brain and spinal cord.