Neurologic Deficits Involving Both Upper and Lower Motor Neurons
One of the clues to a diagnosis of ALS is the involvement of both upper and lower motor neurons. There is an insidious progression along the neuraxis. The pathology of trichothecenes could explain this pattern. Marcesca, M. 201330 reports on the transport of food-associated trichothecenes from the gut to the brain. The ready movement of T-2 toxin across the blood brain barrier leads to its accumulation in the brain and spinal cord.