2.2 Study Design
ITD Group: ITD Group included 62 patients who were all
diagnosed with Méniere’s disease (83 ears). Méniere’s disease is
strictly diagnosed according to the symptom complex, including episodic
vertigo, aural fullness, tinnitus and hearing loss. All patients had
complete audiologic and caloric examination. Then, ITD Group was further
divided into ITD1 group and ITD2 group.ITD1 Group: 31 patients (41 ears)
were treated with 2mg/ml Dexamethasone. ITD2Group: 31 patients (42 ears)
were treated with 5mg/ml Dexamethasone. Injectable dexamethasone was
induced in ear drum under the guidance of ear endoscopy. The patient
lied on his side with the ears of dexamethasone added upwards to immerse
the round window membrane in the solution for an appropriate time. The
patient was lied with the ear up for 20 minutes, so that the round
window membrane would be bathed in the solution for a proper time.
Patients received ITD every three days for a total of ten times.
ITL Group: In order to more accurately evaluate the
complication characteristics of Méniere’s disease patients treated with
ITD, another 62 patients (91 ears) treated with ITL were set asrandomized control . The method and frequency of tympanic
injection were the same as the ITD group.
Throughout the course of treatment, All the patients in both groups
received the same regimen of oral medication to improve the inner ear
microcirculation and neural function. The medication regimen is as
follows: betahistine 12mg tid and mecobalamin 0.5mg tid .