Results
Evaluation was made of a total of 102 children, comprising 51 (50%) in
the NE group (51% males, 49% females) and 51 (50%) in the control
group (54.9% males, 45.1% females). No significant difference was
found between the two groups in terms of gender distribution. The
average weight of the cases was 3255.7±417.98 gr in the NE group and
3318.8±369.25 gr in the control group. No significant difference was
determined between the two groups in respect of birth weight, and the
birth week distribution was similar in both groups (Table 1).
The laboratory test results of the NE group and control group were
compared. The mean leukocyte and neutrophil values were significantly
higher in the NE group, and there was no difference in the mean platelet
values. There was no significant difference between the NE group and the
control group in terms of the median MPV value, and the median
lymphocyte value was significantly higher in the NE group than in the
control group (Table 2).
ROC curves were plotted to compare the predictive values of leukocyte,
neutrophil and lymphocyte in all 102 patients. As a result of the
analysis, for the leukocyte value of ≥14.99 10e3/uL, the area under the
curve (AUC) was determined to be 0.908 (p<0.001) with 84.3%
sensitivity and 80.4% specificity. For the neutrophil value of ≥8.18
10e3/uL, AUC: 0.921 (p<0.001) was determined with 88.2%
sensitivity and 88.2% specificity. For the lymphocyte value of ≥ 4.91
10e3/uL, AUC: 0.641, (p=0.022) was determined with 62.7% sensitivity
and 60.8% specificity. The ROC analysis showed no statistical
significance for MPV (AUC: 0404, p = 0.094) and thrombocyte (AUC: 0.424,
p = 0.184) (Figure 1).
The changes in the results of the blood count analysis of the cases in
the NE group during the TH process were analyzed. As a result of the
analysis, a significant difference was observed in the leukocyte,
neutrophil, MPV and platelet measurements taken in the first 6 hours of
life from the values measured after 24 and 72 hours of TH treatment. No
significant difference was found in lymphocyte measurements (Table 3).
The leukocyte and neutrophil levels were determined to be high before TH
treatment, and significantly decreased at 24 and 72 hours of TH
treatment. In the first 24 hours of TH treatment, it was found that the
platelet count decreased and MPV levels increased, and there was no
significant change in the platelet count and MPV levels during the
continuation of the treatment (Table 4).