References
  1. Li B, Concepcion K, Meng X, Zhang L. Brain-immune interactions in perinatal hypoxic-ischemic brain injury. Prog Neurobiol. 2017;159:50-68
  2. Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab . 2015;35(6):888-901
  3. Perez-de-Puig I, Miró-Mur F, Ferrer-Ferrer M, et al. Neutrophil recruitment to the brain in mouse and human ischemic stroke. Acta Neuropathol . 2015;129(2):239-57
  4. Wang G, Guo Q, Hossain M, et al. Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice. Brain Res. 2009;1294:183-92
  5. Allen C, Thornton P, Denes A, et al. Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J Immunol 2012;189(1):381-92
  6. Garcia-Bonilla L, Racchumi G, Murphy M, Anrather J, Iadecola C. Endothelial CD36 Contributes to Postischemic Brain Injury by Promoting Neutrophil Activation via CSF3. J Neurosci . 2015;35(44):14783-93
  7. Silveira RC, Procianoy RS. Hypothermia therapy for newborns with hypoxic ischemic encephalopathy. J Pediatr (Rio J). 2015;91(6 Suppl 1):78-83.
  8. Datta V. Therapeutic Hypothermia for Birth Asphyxia in Neonates. Indian J Pediatr. 2017;84(3):219-26
  9. Millar LJ, Shi L, Hoerder-Suabedissen A, Molnár Z. Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges. Front Cell Neurosci. 2017;11:78
  10. Mirabelli-Badenier M, Braunersreuther V, Lenglet S, et al. Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury. Eur J Clin Invest. 2012;42(7):784-94
  11. Nacaroglu HT, Erdem SB, Karaman S, Yazici S, Can D. Can mean platelet volume and neutrophil-to-lymphocyte ratio be biomarkers of acute exacerbation of bronchiectasis in children? Cent Eur J Immunol. 2017;42(4):358-62
  12. İşgüder R, Ceylan G, Ağın H, et al. Increased mean platelet volume in children with sepsis as a predictor of mortality. Turk J Pediatr. 2016;58(5):503-11
  13. Renshaw AA, Drago B, Toraya N, Gould EW. Respiratory syncytial virus infection is strongly correlated with decreased mean platelet volume. Int J Infect Dis. 2013;17(9):678-80
  14. González-Ibarra FP, Varon J, López-Meza EG. Therapeutic hypothermia: critical review of the molecular mechanisms of action. Front Neurol. 2011;2:4
  15. Perlman JM, Wyllie J, Kattwinkel J, et al. Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. 2010;122(16 Suppl 2):516-38.
  16. Silveira RC, Procianoy RS. Hypothermia therapy for newborns with hypoxic ischemic encephalopathy. J Pediatr (Rio J). 2015;91(6 Suppl 1):78-83.
  17. Mirabelli-Badenier M, Braunersreuther V, Lenglet S, et al. Pathophysiological role of inflammatory molecules in paediatric ischaemic brain injury. Eur J Clin Invest. 2012;42(7):784-94
  18. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000;407(6805):802-9
  19. Wassink G, Gunn ER, Drury PP, Bennet L, Gunn AJ. The mechanisms and treatment of asphyxial encephalopathy. Front Neurosci. 2014;8:40
  20. Hudome S, Palmer C, Roberts RL, Mauger D, Housman C, Towfighi J. The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatr Res. 1997;41(5):607-16
  21. Shah V, Beyene J, Shah P, Perlman M. Association between hematologic findings and brain injury due to neonatal hypoxic-ischemic encephalopathy. Am J Perinatol. 2009;26(4):295-302
  22. Jenkins DD, Lee T, Chiuzan C, et al. Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy*. Pediatr Crit Care Med. 2013;14(8):786-95
  23. Mosalli R. Whole body cooling for infants with hypoxic-ischemic encephalopathy. J Clin Neonatol. 2012;1(2):101-6
  24. Ceulemans AG, Zgavc T, Kooijman R, Hachimi-Idrissi S, Sarre S, Michotte Y. The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia. J Neuroinflammation. 2010;7:74
  25. Chandra H, Chandra S, Rawat A, Verma SK. Role of mean platelet volume as discriminating guide for bone marrow disease in patients with thrombocytopenia. Int J Lab Hematol. 2010;32(5):498-505.
  26. Oncel MY, Ozdemir R, Yurttutan S, et al. Mean platelet volume in neonatal sepsis. J Clin Lab Anal. 2012;26(6):493-6
  27. Tekin M, Konca C, Kahramaner Z, et al. The association between mean platelet volume and infants with meconium stained amniotic fluid. Eur Rev Med Pharmacol Sci. 2016;20(14):2983-7
  28. Kannar V, Deepthi A, Harendra Kumar ML, Junjegowda K, Mariyappa N. Effect of gestational age, prematurity and birth asphyxia on platelet indices in neonates. J Clin Neonatol 2014;3:144-7
Table 1.Sociodemographic characteristics of perinatal asphyxia and control group cases