Results
Evaluation was made of a total of 102 children, comprising 51 (50%) in the NE group (51% males, 49% females) and 51 (50%) in the control group (54.9% males, 45.1% females). No significant difference was found between the two groups in terms of gender distribution. The average weight of the cases was 3255.7±417.98 gr in the NE group and 3318.8±369.25 gr in the control group. No significant difference was determined between the two groups in respect of birth weight, and the birth week distribution was similar in both groups (Table 1).
The laboratory test results of the NE group and control group were compared. The mean leukocyte and neutrophil values were significantly higher in the NE group, and there was no difference in the mean platelet values. There was no significant difference between the NE group and the control group in terms of the median MPV value, and the median lymphocyte value was significantly higher in the NE group than in the control group (Table 2).
ROC curves were plotted to compare the predictive values of leukocyte, neutrophil and lymphocyte in all 102 patients. As a result of the analysis, for the leukocyte value of ≥14.99 10e3/uL, the area under the curve (AUC) was determined to be 0.908 (p<0.001) with 84.3% sensitivity and 80.4% specificity. For the neutrophil value of ≥8.18 10e3/uL, AUC: 0.921 (p<0.001) was determined with 88.2% sensitivity and 88.2% specificity. For the lymphocyte value of ≥ 4.91 10e3/uL, AUC: 0.641, (p=0.022) was determined with 62.7% sensitivity and 60.8% specificity. The ROC analysis showed no statistical significance for MPV (AUC: 0404, p = 0.094) and thrombocyte (AUC: 0.424, p = 0.184) (Figure 1).
The changes in the results of the blood count analysis of the cases in the NE group during the TH process were analyzed. As a result of the analysis, a significant difference was observed in the leukocyte, neutrophil, MPV and platelet measurements taken in the first 6 hours of life from the values measured after 24 and 72 hours of TH treatment. No significant difference was found in lymphocyte measurements (Table 3).
The leukocyte and neutrophil levels were determined to be high before TH treatment, and significantly decreased at 24 and 72 hours of TH treatment. In the first 24 hours of TH treatment, it was found that the platelet count decreased and MPV levels increased, and there was no significant change in the platelet count and MPV levels during the continuation of the treatment (Table 4).