5 Conclusions
In conclusion, IL-28B significantly inhibited colon cancer growth. M2
macrophages mainly mediate IL-28B anti-tumor effects, suggesting that
IL-28B inhibited M2 macrophage polarization via the JNK and STAT3
pathways to exert anti-tumor activity. Our study provides evidence for
IL-28B-mediated regulation of immune cells and its potential in colon
cancer treatment.