Funding statement
This work was supported by the National Natural Science Foundation of China (no. 81874169, 81801557, 81671632), Shandong Provincial Natural Science Foundation Key Project (no. ZR2020KH033), Chinese and foreign cooperation cultivation project of Jining Medical University and NSFC cultivation project of Jining Medical University (no. JYP2018KJ22), and Doctoral Startup Fund of Jining Medical University (no. JY2016QD030).