5 Conclusions
In conclusion, IL-28B significantly inhibited colon cancer growth. M2 macrophages mainly mediate IL-28B anti-tumor effects, suggesting that IL-28B inhibited M2 macrophage polarization via the JNK and STAT3 pathways to exert anti-tumor activity. Our study provides evidence for IL-28B-mediated regulation of immune cells and its potential in colon cancer treatment.