As interim editor-in-chief for the year 2020, and now appointed EiC for the three-year period starting 2021, I have been reflecting on what focus I wish to bring to CiSE. Certainly, the early concerns about the hurdles of interdisciplinarity, and the educational needs of the new generations of computational scientists, are high on my list. Revisiting the role of the Python ecosystem in computational science seems timely now, with the recent convergence with GPU computing via projects to develop open-source libraries giving access to GPU devices from Python programs. In general, I aim for a heightened emphasis on open source research software, combined with attention for transparency and reproducibility. I was a member of the study committee of the National Academies that produced the consensus report on Replicability and Reproducibility in Science last year \cite{2019}, and it has been a long-time area of focus in my own research. Even if CiSE featured the topic in 2009 and 2012, it has trended mainstream only recently—it is time to integrate those considerations firmly into the publication process.