Long term survival
There was no difference in survival between group 1 and 2; survival was
87% versus 84%, p=0.575 at 1 year, 64% versus 66%, p=0.880 at 5
years, 33% versus 57%, p=0.062 at 10 years, respectively (Figure 1A
and supplementary Table 1).
Among patients who were discharged alive from hospital, those with
postoperative complications had a lower survival compared with patients
who had an uncomplicated postoperative course (p=0.023) (Figure 1C,
supplementary Table 1). Survival was worse up to 5 years in those with a
cardiovascular injury at re-sternotomy (46% versus 67%, p=0.025,
Figure 1B and supplementary Table 1).
Postoperative complications, age and history of cerebrovascular accident
were independent predictors of long term survival (Table 5).
The survival probability for the overall cohort with re-sternotomy was
85% (SE: 2.7%), 65% (SE: 3.7%), 44% (SE: 4.2%) and 17% (SE:
4.5%) at 1-year, 5-years, 10-years and 15-years, respectively, and was
significantly lower than the age matched survival of patients who had
first time AVR +/- other procedure(s) and the age matched survival of UK
population (Figure 2).